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    GNAI2 G protein subunit alpha i2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281791, updated on 4-Oct-2024

    Summary

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    Official Symbol
    GNAI2provided by VGNC
    Official Full Name
    G protein subunit alpha i2provided by VGNC
    Primary source
    VGNC:VGNC:29450
    See related
    BGD:BT19436; Ensembl:ENSBTAG00000020645
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HG1C
    Orthologs
    human mouse all
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    Genomic context

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    See GNAI2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50099967..50120142, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene interferon related developmental regulator 2 Neighboring gene leucine rich single-pass membrane protein 2 Neighboring gene semaphorin 3B Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene solute carrier family 38 member 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Parnell SC, et al. Biochem Biophys Res Commun, 1998 Oct 20. PMID 9792824
    2. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Heximer SP, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405622, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(i) subunit alpha-2
    Names
    guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
    guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
    heterotrimeric guanine nucleotide-binding protein 1C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101040.1 → NP_001094510.1  guanine nucleotide-binding protein G(i) subunit alpha-2

      See identical proteins and their annotated locations for NP_001094510.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151571
      UniProtKB/TrEMBL
      A7MBH9, F6RQC9
      Related
      ENSBTAP00000027511.5, ENSBTAT00000027511.6
      Conserved Domains (1) summary
      cd00066
      Location:34 → 349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50099967..50120142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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