CLTB clathrin light chain B [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CLTBprovided by VGNC
Official Full Name: clathrin light chain Bprovided by VGNC
Primary source: VGNC:VGNC:27470
See related: BGD:BT16315; Ensembl:ENSBTAG00000010740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CLTLB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (37859129..37879195, complement)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of clathrin coat with bound Hsc70 and auxilin.
Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
Title: Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.
CLTLB purified from bovine brain postmicrotubule supernatant and identified by mass spectrometry potently inhibited a catalytic activity of a major protein phosphatase (PP) that was copurified with microtubules and recognized by antiPP1 antibodies
Title: Clathrin light chain b is capable of affecting potently a major protein phosphatase from microtubules (MT-PP1).

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_5053-5054:996690093:1 (e-PCR)
- UniSTS:269445

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info	PubMed
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic endocytic zone cytoplasmic component	IEA Inferred from Electronic Annotation more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: clathrin light chain B

Names: clathrin, light chain (Lcb); clathrin, light polypeptide B (light chain B); lcb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.