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    UACA uveal autoantigen with coiled-coil domains and ankyrin repeats [ Bos taurus (domestic cattle) ]

    Gene ID: 281559, updated on 4-Oct-2024

    Summary

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    Official Symbol
    UACAprovided by VGNC
    Official Full Name
    uveal autoantigen with coiled-coil domains and ankyrin repeatsprovided by VGNC
    Primary source
    VGNC:VGNC:36558
    See related
    BGD:BT15292; Ensembl:ENSBTAG00000013982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See UACA in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (17533608..17619278, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346337 Neighboring gene microRNA mir-2285ar Neighboring gene ubiquitin-conjugating enzyme E2 N-like Neighboring gene uncharacterized LOC132346338 Neighboring gene La ribonucleoprotein 6, translational regulator Neighboring gene THAP domain containing 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Betacap73-ARF6 interactions modulate cell shape and motility after injury in vitro. Riley KN, et al. Mol Biol Cell, 2003 Oct. PMID 14517325, Free PMC Article
    2. Cloning and characterization of betaCAP73, a novel regulator of beta-actin assembly. Welch AY, et al. Int J Biochem Cell Biol, 2002 Jul. PMID 11950601
    3. Identification of a novel autoantigen UACA in patients with panuveitis. Yamada K, et al. Biochem Biophys Res Commun, 2001 Feb 2. PMID 11162650
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uveal autoantigen with coiled-coil domains and ankyrin repeats protein
    Names
    beta-actin-binding protein
    betaCAP73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174209.2 → NP_776634.1  uveal autoantigen with coiled-coil domains and ankyrin repeats protein

      See identical proteins and their annotated locations for NP_776634.1

      Status: PROVISIONAL

      Source sequence(s)
      AY152693
      UniProtKB/Swiss-Prot
      Q8HYY4
      UniProtKB/TrEMBL
      F1MKQ9
      Related
      ENSBTAP00000025640.5, ENSBTAT00000025640.6
      Conserved Domains (7) summary
      pfam05483
      Location:219 → 1009
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG2604
      Location:881 → 1015
      COG2604; Uncharacterized conserved protein [Function unknown]
      PRK03918
      Location:748 → 1309
      PRK03918; chromosome segregation protein; Provisional
      cd00204
      Location:85 → 207
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:92 → 184
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:187 → 239
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:121 → 151
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17533608..17619278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010808862.4 → XP_010807164.1  uveal autoantigen with coiled-coil domains and ankyrin repeats protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LN88, F1MKQ9
      Related
      ENSBTAP00000061426.2, ENSBTAT00000075718.2
      Conserved Domains (7) summary
      pfam05483
      Location:234 → 1024
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      COG2604
      Location:896 → 1030
      COG2604; Uncharacterized conserved protein [Function unknown]
      PRK03918
      Location:763 → 1324
      PRK03918; chromosome segregation protein; Provisional
      cd00204
      Location:100 → 222
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:107 → 199
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:202 → 254
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:136 → 166
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8HYY4.1 GenPept UniProtKB/Swiss-Prot:Q8HYY4

    Gene LinkOut

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