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    TPM1 tropomyosin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281544, updated on 4-Oct-2024

    Summary

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    Official Symbol
    TPM1provided by VGNC
    Official Full Name
    tropomyosin 1provided by VGNC
    Primary source
    VGNC:VGNC:106994
    See related
    BGD:BT10015; Ensembl:ENSBTAG00000005373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Note: GeneIDs 100336949 and 281544 are annotated independently on Bos_taurus_UMD_3.1.1 but may be redundant loci. [04 Feb 2015]
    Orthologs
    human mouse all
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    Genomic context

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    See TPM1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (46993263..47022836, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 like Neighboring gene lactamase beta Neighboring gene uncharacterized LOC132346368 Neighboring gene microRNA mir-190a Neighboring gene talin 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges. Bai F, et al. PLoS One, 2012. PMID 23077624, Free PMC Article
    2. The effect of tropomyosin on force and elementary steps of the cross-bridge cycle in reconstituted bovine myocardium. Fujita H, et al. J Physiol, 2004 Apr 15. PMID 14742733, Free PMC Article
    3. Effects of tropomyosin internal deletion Delta23Tm on isometric tension and the cross-bridge kinetics in bovine myocardium. Lu X, et al. J Physiol, 2003 Dec 1. PMID 14500764, Free PMC Article
    4. Folding properties of functional domains of tropomodulin. Kostyukova AS, et al. Biophys J, 2001 Jul. PMID 11423419, Free PMC Article
    5. The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium. Bai F, et al. J Mol Cell Cardiol, 2015 Feb. PMID 25451174

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The first step of hypertrophic cardiomyopathy pathogenesis with E99K is increased calcium sensitivity and decreased calcium cooperativity, which result in larger tension during partial activation to cause a diastolic problem.
      Title: The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium.
    2. over-inhibition of the actomyosin interaction by E40K and E54K Tm mutants leads to a decreased force-generating ability at systole, which is the main mechanism underlying the early pathogenesis of DCM.
      Title: DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges.
    3. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.
      Title: Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.
    4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules
      Title: Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant.
    5. Tropomyosin is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.
      Title: The effect of tropomyosin on force and elementary steps of the cross-bridge cycle in reconstituted bovine myocardium.
    6. Deletion of regions 2-3 in tropomyosin alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin-reconstituted myocardium.
      Title: Effects of tropomyosin internal deletion Delta23Tm on isometric tension and the cross-bridge kinetics in bovine myocardium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tropomyosin alpha-1 chain
    Names
    tropomyosin 1 (alpha)
    tropomyosin 1 alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013590.2 → NP_001013608.1  tropomyosin alpha-1 chain

      See identical proteins and their annotated locations for NP_001013608.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102909
      UniProtKB/Swiss-Prot
      Q5KR49
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      46993263..47022836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997253.2 → XP_024853021.1  tropomyosin alpha-1 chain isoform X9

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    2. XM_024997259.2 → XP_024853027.1  tropomyosin alpha-1 chain isoform X13

      UniProtKB/TrEMBL
      A0AAF6ZFK7
      Related
      ENSBTAP00000042255.5, ENSBTAT00000044796.5
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    3. XM_024997256.2 → XP_024853024.1  tropomyosin alpha-1 chain isoform X11

      UniProtKB/TrEMBL
      A0AAA9TTT0
      Related
      ENSBTAP00000099946.1, ENSBTAT00000100322.1
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    4. XM_024997260.2 → XP_024853028.1  tropomyosin alpha-1 chain isoform X14

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    5. XM_059890209.1 → XP_059746192.1  tropomyosin alpha-1 chain isoform X21

      UniProtKB/TrEMBL
      A0A3Q1LPQ6
      Related
      ENSBTAP00000058989.2, ENSBTAT00000074743.2

    6. XM_024997246.2 → XP_024853014.1  tropomyosin alpha-1 chain isoform X2

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    7. XM_024997249.2 → XP_024853017.1  tropomyosin alpha-1 chain isoform X4

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    8. XM_059890204.1 → XP_059746187.1  tropomyosin alpha-1 chain isoform X17

    9. XM_059890206.1 → XP_059746189.1  tropomyosin alpha-1 chain isoform X19

    10. XM_059890205.1 → XP_059746188.1  tropomyosin alpha-1 chain isoform X18

    11. XM_059890207.1 → XP_059746190.1  tropomyosin alpha-1 chain isoform X20

    12. XM_024997250.2 → XP_024853018.1  tropomyosin alpha-1 chain isoform X7

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 244
      Tropomyosin

    13. XM_024997251.2 → XP_024853019.1  tropomyosin alpha-1 chain isoform X8

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 244
      Tropomyosin

    14. XM_059890212.1 → XP_059746195.1  tropomyosin alpha-1 chain isoform X24

    15. XM_059890213.1 → XP_059746196.1  tropomyosin alpha-1 chain isoform X25

    16. XM_024997257.2 → XP_024853025.1  tropomyosin alpha-1 chain isoform X12

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    17. XM_059890214.1 → XP_059746197.1  tropomyosin alpha-1 chain isoform X26

    18. XM_024997254.2 → XP_024853022.1  tropomyosin alpha-1 chain isoform X10

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    19. XM_059890215.1 → XP_059746198.1  tropomyosin alpha-1 chain isoform X27

    20. XM_024997244.2 → XP_024853012.1  tropomyosin alpha-1 chain isoform X1

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    21. XM_059890216.1 → XP_059746199.1  tropomyosin alpha-1 chain isoform X28

    22. XM_024997247.2 → XP_024853015.1  tropomyosin alpha-1 chain isoform X3

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    23. XM_024997255.2 → XP_024853023.1  tropomyosin alpha-1 chain isoform X15

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    24. XM_059890203.1 → XP_059746186.1  tropomyosin alpha-1 chain isoform X16

    25. XM_059890211.1 → XP_059746194.1  tropomyosin alpha-1 chain isoform X23

    26. XM_059890210.1 → XP_059746193.1  tropomyosin alpha-1 chain isoform X22

    27. XM_024997245.2 → XP_024853013.1  tropomyosin alpha-1 chain isoform X5

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin

    28. XM_024997248.2 → XP_024853016.1  tropomyosin alpha-1 chain isoform X6

      Conserved Domains (1) summary
      pfam00261
      Location:12 → 246
      Tropomyosin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5KR49.1 GenPept UniProtKB/Swiss-Prot:Q5KR49

    Gene LinkOut

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