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    MBL2 mannose binding lectin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281297, updated on 4-Oct-2024

    Summary

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    Official Symbol
    MBL2provided by VGNC
    Official Full Name
    mannose binding lectin 2provided by VGNC
    Primary source
    VGNC:VGNC:31280
    See related
    BGD:BT27697; Ensembl:ENSBTAG00000007049
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MBL
    Orthologs
    human mouse all
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    Genomic context

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    See MBL2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (6332002..6337539)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene protocadherin related 15 Neighboring gene quinone oxidoreductase-like Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene hydroxyacyl-CoA dehydrogenase pseudogene Neighboring gene centromere protein W-like Neighboring gene transfer RNA lysine (anticodon CUU)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins. Zhao ZL, et al. Genet Mol Res, 2012 Oct 15. PMID 23096694
    2. The relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and complement activity. Wang X, et al. Vet Immunol Immunopathol, 2012 Aug 15. PMID 22771198
    3. Cloning and characterization of a cDNA encoding bovine mannan-binding protein. Kawai T, et al. Gene, 1997 Feb 28. PMID 9074491
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannose-binding protein C
    Names
    MBP-C
    mannan-binding protein
    mannose-binding lectin (protein C) 2, soluble (opsonic defect)
    mannose-binding lectin-C
    soluble mannose-binding lectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174107.2 → NP_776532.1  mannose-binding protein C precursor

      See identical proteins and their annotated locations for NP_776532.1

      Status: PROVISIONAL

      Source sequence(s)
      D73408
      UniProtKB/Swiss-Prot
      A4IFQ1, O02659
      Conserved Domains (2) summary
      pfam01391
      Location:40 → 81
      Collagen; Collagen triple helix repeat (20 copies)
      cl02432
      Location:137 → 247
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      6332002..6337539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005225352.5 → XP_005225409.1  mannose-binding protein C isoform X1

      See identical proteins and their annotated locations for XP_005225409.1

      UniProtKB/Swiss-Prot
      A4IFQ1, O02659
      Related
      ENSBTAP00000009270.1, ENSBTAT00000009270.3
      Conserved Domains (2) summary
      pfam01391
      Location:40 → 81
      Collagen; Collagen triple helix repeat (20 copies)
      cl02432
      Location:137 → 247
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02659.1 GenPept UniProtKB/Swiss-Prot:O02659

    Gene LinkOut

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