U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LDHB lactate dehydrogenase B [ Bos taurus (domestic cattle) ]

    Gene ID: 281275, updated on 18-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LDHBprovided by VGNC
    Official Full Name
    lactate dehydrogenase Bprovided by VGNC
    Primary source
    VGNC:VGNC:30824
    See related
    BGD:BT14803; Ensembl:ENSBTAG00000019603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Pseudogenes have been identified on chromosomes 1 and 11. [provided by RefSeq, Oct 2015]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (88544523..88562770)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 9 Neighboring gene uncharacterized LOC132345331 Neighboring gene potassium inwardly rectifying channel subfamily J member 8 Neighboring gene glycogen synthase 2 Neighboring gene spexin hormone

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals. Schueren F, et al. Elife, 2014 Sep 23. PMID 25247702, Free PMC Article
    2. Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals. Stiebler AC, et al. PLoS Genet, 2014 Oct. PMID 25340584, Free PMC Article
    3. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
    4. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
    5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    L-lactate dehydrogenase B chain
    Names
    LDH-B
    NP_001303267.1
    NP_776525.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316338.1 → NP_001303267.1  L-lactate dehydrogenase B chain isoform LDHBx

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (LDHB) results from translation termination at the upstream UGA stop codon, while the longer isoform (LDHBx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (LDHBx), which is localized in the peroxisomes. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      BC142006, DT720873, EE338507
      UniProtKB/TrEMBL
      B0JYN3
      Conserved Domains (2) summary
      cd05293
      Location:20 → 330
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:26 → 325
      L-LDH-NAD; L-lactate dehydrogenase

    2. NM_174100.2 → NP_776525.2  L-lactate dehydrogenase B chain isoform LDHB

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (LDHB) results from translation termination at the upstream UGA stop codon, while the longer isoform (LDHBx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (LDHB), which is localized in the cytosol.
      Source sequence(s)
      BC142006, DT720873, EE338507
      UniProtKB/Swiss-Prot
      A5PJ87, Q3T0X4, Q5E9B1, Q9MYV5
      UniProtKB/TrEMBL
      B0JYN3
      Related
      ENSBTAP00000026118.5, ENSBTAT00000026118.6
      Conserved Domains (1) summary
      cd05293
      Location:20 → 330
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      88544523..88562770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9B1.4 GenPept UniProtKB/Swiss-Prot:Q5E9B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.