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    IDH1 isocitrate dehydrogenase (NADP(+)) 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281235, updated on 17-Aug-2024

    Summary

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    Gene symbol
    IDH1
    Gene description
    isocitrate dehydrogenase (NADP(+)) 1
    See related
    BGD:BT25484; Ensembl:ENSBTAG00000020527
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IDPc
    Orthologs
    human mouse all
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    Genomic context

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    See IDH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (96510378..96531400, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group PABLB member 1 Env polyprotein-like Neighboring gene microRNA mir-2285ax-2 Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene male-specific lethal 3 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium: Modulation by regulators of differentiation and metabolic effectors. Liu W, et al. Exp Biol Med (Maywood), 2006 May. PMID 16636309
    2. Identification of a cytosolic NADP+-dependent isocitrate dehydrogenase that is preferentially expressed in bovine corneal epithelium. A corneal epithelial crystallin. Sun L, et al. J Biol Chem, 1999 Jun 11. PMID 10358094
    3. Bovine NAD+-dependent isocitrate dehydrogenase: alternative splicing and tissue-dependent expression of subunit 1. Weiss C, et al. Biochemistry, 2000 Feb 22. PMID 10677231
    4. Identification of intracellular target proteins of the calcium-signaling protein S100A12. Hatakeyama T, et al. Eur J Biochem, 2004 Sep. PMID 15355353
    5. Housekeeping genes for phylogenetic analysis of eutherian relationships. Kullberg M, et al. Mol Biol Evol, 2006 Aug. PMID 16751257

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isocitrate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    IDH
    IDP
    NADP(+)-specific ICDH
    cytosolic NADP-isocitrate dehydrogenase
    isocitrate dehydrogenase (NADP(+)) 1, cytosolic
    isocitrate dehydrogenase 1 (NADP+), soluble
    oxalosuccinate decarboxylase
    NP_851355.2
    XP_005202754.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181012.3 → NP_851355.2  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_851355.2

      Status: PROVISIONAL

      Source sequence(s)
      BC103368
      UniProtKB/Swiss-Prot
      Q3SYV2, Q9XSG3
      UniProtKB/TrEMBL
      A0A140T8A5
      Related
      ENSBTAP00000027348.2, ENSBTAT00000027348.4
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      96510378..96531400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202697.3 → XP_005202754.1  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_005202754.1

      UniProtKB/Swiss-Prot
      Q3SYV2, Q9XSG3
      UniProtKB/TrEMBL
      A0A140T8A5
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XSG3.1 GenPept UniProtKB/Swiss-Prot:Q9XSG3

    Gene LinkOut

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