U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FSHR follicle stimulating hormone receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 281172, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FSHRprovided by VGNC
    Official Full Name
    follicle stimulating hormone receptorprovided by VGNC
    Primary source
    VGNC:VGNC:29132
    See related
    Ensembl:ENSBTAG00000032424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FSHR in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (31255649..31450534, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIA subunit 1 like Neighboring gene uncharacterized LOC132346571 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene uncharacterized LOC132346572 Neighboring gene uncharacterized LOC132346513

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. FSHR genotype affects estrogen levels but not pregnancy rates in Luxi cattle subjected to embryo transfer. Yang WC, et al. Genet Mol Res, 2014 Mar 12. PMID 24668630
    2. Identification of single nucleotide polymorphisms in the bovine follicle-stimulating hormone receptor and effects of genotypes on superovulatory response traits. Cory AT, et al. Anim Genet, 2013 Apr. PMID 22670622
    3. Structure of the bovine follicle-stimulating hormone receptor complementary DNA and expression in bovine tissues. Houde A, et al. Mol Reprod Dev, 1994 Oct. PMID 7826612
    4. mRNA expression pattern of gonadotropin receptors in bovine follicular cysts. Marelli BE, et al. Reprod Biol, 2014 Dec. PMID 25454493
    5. Effects of polymorphisms of LHR and FSHR genes on sexual precocity in a Bos taurus x Bos indicus beef composite population. Marson EP, et al. Genet Mol Res, 2008 Mar 11. PMID 18393228

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
      Title: INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS (EAST ANATOLLAN RED, SOUTH ANATOLIAN RED, TURKISH GREY, ANATOLIAN BLACK AND ZAVOT).
    2. The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts.
      Title: mRNA expression pattern of gonadotropin receptors in bovine follicular cysts.
    3. transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle.
      Title: FSHR genotype affects estrogen levels but not pregnancy rates in Luxi cattle subjected to embryo transfer.
    4. Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
      Title: Identification of single nucleotide polymorphisms in the bovine follicle-stimulating hormone receptor and effects of genotypes on superovulatory response traits.
    5. This study evaluated the relationships among aromatase, IGF-1, IGF2R, and follicle stimulating hormone (FSH) receptor levels expressed in ovarian follicles of cattle selected for twin pregnancies.
      Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
    6. Heterozygous heifers showed a higher pregnancy rate (67 and 66% for LHR and FSHR genes, respectively), but no significant effects were observed for the genes studied (
      Title: Effects of polymorphisms of LHR and FSHR genes on sexual precocity in a Bos taurus x Bos indicus beef composite population.
    7. FSHR is specifically regulated through androgen receptor in granulosa cells
      Title: Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells.
    8. Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves.
      Title: Molecular evidence that growth of dominant follicles involves a reduction in follicle-stimulating hormone dependence and an increase in luteinizing hormone dependence in cattle.
    9. granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production
      Title: Temporal relationships between FSH receptor, type 1 insulin-like growth factor receptor, and aromatase expression during FSH-induced differentiation of bovine granulosa cells maintained in serum-free culture.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables follicle-stimulating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in follicle-stimulating hormone signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    follicle-stimulating hormone receptor
    Names
    FSH-R
    follitropin receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174061.1 → NP_776486.1  follicle-stimulating hormone receptor precursor

      See identical proteins and their annotated locations for NP_776486.1

      Status: PROVISIONAL

      Source sequence(s)
      L22319
      UniProtKB/Swiss-Prot
      P35376
      UniProtKB/TrEMBL
      F1MT42
      Related
      ENSBTAP00000048971.2, ENSBTAT00000056513.3
      Conserved Domains (6) summary
      smart00013
      Location:17 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:379 → 626
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam12369
      Location:282 → 349
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13306
      Location:61 → 216
      LRR_5; Leucine rich repeats (6 copies)
      pfam13855
      Location:193 → 245
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      31255649..31450534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059890999.1 → XP_059746982.1  follicle-stimulating hormone receptor isoform X3

      UniProtKB/TrEMBL
      F1MT42

    2. XM_059890998.1 → XP_059746981.1  follicle-stimulating hormone receptor isoform X2

      UniProtKB/TrEMBL
      F1MT42

    3. XM_024998262.2 → XP_024854030.1  follicle-stimulating hormone receptor isoform X5

      UniProtKB/TrEMBL
      F1MT42
      Conserved Domains (6) summary
      smart00013
      Location:17 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:99 → 122
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:72 → 93
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:232 → 299
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:143 → 195
      LRR_8; Leucine rich repeat
      cd15360
      Location:313 → 587
      7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_024998260.2 → XP_024854028.1  follicle-stimulating hormone receptor isoform X1

      UniProtKB/TrEMBL
      F1MT42
      Conserved Domains (6) summary
      smart00013
      Location:17 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:51 → 71
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:281 → 348
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:72 → 131
      LRR_8; Leucine rich repeat
      cd15360
      Location:362 → 636
      7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:61 → 215
      LRR_5; Leucine rich repeats (6 copies)

    5. XM_024998261.2 → XP_024854029.1  follicle-stimulating hormone receptor isoform X4

      UniProtKB/TrEMBL
      A0AAA9SWP4
      Conserved Domains (7) summary
      smart00013
      Location:17 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:170 → 193
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:232 → 299
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      pfam13855
      Location:143 → 195
      LRR_8; Leucine rich repeat
      cd15360
      Location:313 → 587
      7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:58 → 166
      LRR_5; Leucine rich repeats (6 copies)

    6. XM_024998263.2 → XP_024854031.1  follicle-stimulating hormone receptor isoform X6

      UniProtKB/TrEMBL
      F1MT42
      Conserved Domains (5) summary
      smart00013
      Location:17 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:72 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12369
      Location:224 → 287
      GnHR_trans; Gonadotropin hormone receptor transmembrane region
      cd15360
      Location:301 → 575
      7tmA_FSH-R; follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
      cl26222
      Location:61 → 216
      LRR_5; Leucine rich repeats (6 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35376.1 GenPept UniProtKB/Swiss-Prot:P35376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials