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    CSH2 chorionic somatomammotropin hormone 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281097, updated on 12-Oct-2024

    Summary

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    Gene symbol
    CSH2
    Gene description
    chorionic somatomammotropin hormone 2
    See related
    Ensembl:ENSBTAG00000006761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PL; PL1; CSH1
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    Genomic context

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    See CSH2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (35287200..35299843)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene placental prolactin-related protein 3-like Neighboring gene chorionic somatomammotropin hormone 1-like Neighboring gene prolactin Neighboring gene HDGF like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 genes. Nakaya Y, et al. BMC Mol Biol, 2009 Mar 5. PMID 19261194, Free PMC Article
    2. Bovine placental lactogen: molecular cloning and protein structure. Schuler LA, et al. Biochemistry, 1988 Nov 1. PMID 3242594
    3. Structure of the bovine placental lactogen gene and alternative splicing of transcripts. Kessler MA, et al. DNA Cell Biol, 1991 Mar. PMID 2003877
    4. Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies. Ravelich SR, et al. Biol Reprod, 2004 Dec. PMID 15306554
    5. Expression of new members of the prolactin growth hormone gene family in bovine placenta. Isolation and characterization of two prolactin-like cDNA clones. Yamakawa M, et al. J Biol Chem, 1990 May 25. PMID 2341410

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first report to identify the differential regulatory mechanisms of the bCSH1 and bPRP1 genes and indicates that bCSH1 might potentially be the only transcript that is subject to DNA methyltransferase regulation.
      Title: The characterization of DNA methylation-mediated regulation of bovine placental lactogen and bovine prolactin-related protein-1 genes.
    2. Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
      Title: Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes.
    3. Dysregulation of PL and leptin in nuclear transfer placentomes could affect cell migration and invasion and subsequently placental metabolism and transfer of nutrients to fetus, leading to increased placental and fetal macrosomia.
      Title: Altered placental lactogen and leptin expression in placentomes from bovine nuclear transfer pregnancies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables prolactin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mammary gland development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of lactation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chorionic somatomammotropin hormone 2
    Names
    BPLP-I
    BPLP-II
    chorionic somatomammotropin hormone 1 (placental lactogen)
    placental lactogen I
    placental lactogen II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164321.1 → NP_001157793.1  chorionic somatomammotropin hormone 2 isoform 2

      See identical proteins and their annotated locations for NP_001157793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to variant 1.
      Source sequence(s)
      BC149388, CX736016, EE252986
      UniProtKB/TrEMBL
      A0AAA9TSX5, A6QPM4
      Related
      ENSBTAP00000100447.1, ENSBTAT00000112534.1
      Conserved Domains (1) summary
      cd10288
      Location:80 → 237
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_181007.2 → NP_851350.2  chorionic somatomammotropin hormone 2 isoform 1

      See identical proteins and their annotated locations for NP_851350.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC149388, CX736016, EE252986, EV793172
      UniProtKB/Swiss-Prot
      P09611
      UniProtKB/TrEMBL
      F1MYF0
      Related
      ENSBTAP00000035394.6, ENSBTAT00000035519.6
      Conserved Domains (1) summary
      cd10288
      Location:80 → 273
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35287200..35299843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880204.1 → XP_059736187.1  chorionic somatomammotropin hormone 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09611.2 GenPept UniProtKB/Swiss-Prot:P09611
    P19159.1 GenPept UniProtKB/Swiss-Prot:P19159

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.