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    CSF1 colony stimulating factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281094, updated on 10-Oct-2024

    Summary

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    Official Symbol
    CSF1provided by VGNC
    Official Full Name
    colony stimulating factor 1provided by VGNC
    Primary source
    VGNC:VGNC:27753
    See related
    BGD:BT11511; Ensembl:ENSBTAG00000000283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CSF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (33488959..33509047, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene striatin interacting protein 1 Neighboring gene adenosylhomocysteinase like 1 Neighboring gene L-lactate dehydrogenase B chain-like Neighboring gene microRNA mir-2413

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic regulation of expression of colony-stimulating factor 1 in the reproductive tract of cattle during the estrous cycle and in pregnancy. Lee RS, et al. Biol Reprod, 2003 Aug. PMID 12672668
    2. Cloning and sequencing of cDNA encoding bovine macrophage colony-stimulating factor (bM-CSF) and expression of recombinant bM-CSF using baculovirus. Yoshihara K, et al. Vet Immunol Immunopathol, 1998 Jun 12. PMID 9656426
    3. Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy. Oshima K, et al. Theriogenology, 2003 Oct 15. PMID 14511776
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the high level of colony-stimulating factor 1 expression during bovine pregnancy in uteroplacental tissues is consistent with its proposed role in placental physiology
      Title: Dynamic regulation of expression of colony-stimulating factor 1 in the reproductive tract of cattle during the estrous cycle and in pregnancy.
    2. results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor are produced in the endometrium and may play different roles in early and mid-pregnancy
      Title: Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    macrophage colony-stimulating factor 1
    Names
    colony stimulating factor 1 (macrophage)
    NP_776451.1
    XP_005204127.1
    XP_005204128.1
    XP_024840319.1
    XP_059737474.1
    XP_059737482.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174026.1 → NP_776451.1  macrophage colony-stimulating factor 1 precursor

      See identical proteins and their annotated locations for NP_776451.1

      Status: PROVISIONAL

      Source sequence(s)
      D87917
      UniProtKB/TrEMBL
      O77709, Q7YQK0
      Conserved Domains (1) summary
      pfam05337
      Location:273 → 554
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33488959..33509047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881491.1 → XP_059737474.1  macrophage colony-stimulating factor 1 isoform X3

    2. XM_024984551.2 → XP_024840319.1  macrophage colony-stimulating factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LMK4, A0AAA9S983
      Related
      ENSBTAP00000057942.1, ENSBTAT00000076179.2
      Conserved Domains (2) summary
      pfam05337
      Location:41 → 180
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
      cl26464
      Location:196 → 424
      Atrophin-1; Atrophin-1 family

    3. XM_059881499.1 → XP_059737482.1  macrophage colony-stimulating factor 1 isoform X4

    4. XM_005204071.5 → XP_005204128.1  macrophage colony-stimulating factor 1 isoform X5

      See identical proteins and their annotated locations for XP_005204128.1

      UniProtKB/TrEMBL
      O77710, Q6WQW9
      Conserved Domains (1) summary
      pfam05337
      Location:41 → 180
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

    5. XM_005204070.5 → XP_005204127.1  macrophage colony-stimulating factor 1 isoform X2

      See identical proteins and their annotated locations for XP_005204127.1

      UniProtKB/TrEMBL
      F1MGS9, Q7YQK0
      Related
      ENSBTAP00000000353.5, ENSBTAT00000000353.7
      Conserved Domains (1) summary
      pfam05337
      Location:273 → 554
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials