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    CCT8 chaperonin containing TCP1 subunit 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 281047, updated on 12-Oct-2024

    Summary

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    Gene symbol
    CCT8
    Gene description
    chaperonin containing TCP1 subunit 8
    See related
    BGD:BT23519; Ensembl:ENSBTAG00000014233
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CCT8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (7114205..7127950)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene MAP3K7 C-terminal like Neighboring gene uncharacterized LOC100851369 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene RWD domain containing 2B Neighboring gene listerin E3 ubiquitin protein ligase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association of CRISP2, CCT8, PEBP1 mRNA abundance in sperm and sire conception rate in Holstein bulls. Arangasamy A, et al. Theriogenology, 2011 Aug. PMID 21529916
    2. Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin. Muñoz IG, et al. Nat Struct Mol Biol, 2011 Jan. PMID 21151115
    3. Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Leitner A, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24938783, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCT8 mRna levels are associated with male fertility.
      Title: Association of CRISP2, CCT8, PEBP1 mRNA abundance in sperm and sire conception rate in Holstein bulls.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC126936

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-complex protein 1 subunit theta
    Names
    CCT-theta
    TCP-1-theta
    chaperonin containing TCP1, subunit 8 (theta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033609.1 → NP_001028781.1  T-complex protein 1 subunit theta

      See identical proteins and their annotated locations for NP_001028781.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102169
      UniProtKB/Swiss-Prot
      Q3ZCI9
      UniProtKB/TrEMBL
      A0AAA9TPC4
      Related
      ENSBTAP00000018917.2, ENSBTAT00000018917.3
      Conserved Domains (1) summary
      TIGR02346
      Location:10 → 539
      chap_CCT_theta; T-complex protein 1, theta subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7114205..7127950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005201119.5 → XP_005201176.1  T-complex protein 1 subunit theta isoform X1

      See identical proteins and their annotated locations for XP_005201176.1

      UniProtKB/TrEMBL
      A0A3Q1MTL6, A0AAA9TPC4
      Related
      ENSBTAP00000073681.2, ENSBTAT00000085042.2
      Conserved Domains (1) summary
      TIGR02346
      Location:10 → 539
      chap_CCT_theta; T-complex protein 1, theta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZCI9.3 GenPept UniProtKB/Swiss-Prot:Q3ZCI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.