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    ZP2 zona pellucida glycoprotein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 280963, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ZP2provided by VGNC
    Official Full Name
    zona pellucida glycoprotein 2provided by VGNC
    Primary source
    VGNC:VGNC:37366
    See related
    BGD:BT10372; Ensembl:ENSBTAG00000011504
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    Zp-2
    Orthologs
    human mouse all
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    Genomic context

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    See ZP2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (19019145..19055627, complement)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 3 Neighboring gene protein SET-like Neighboring gene lipid droplet assembly factor 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B Neighboring gene crystallin mu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of N-linked carbohydrate chains in glycoprotein ZPA of the bovine egg zona pellucida. Ikeda K, et al. Eur J Biochem, 2002 Sep. PMID 12199704
    2. Evolutionary patterns of two major reproduction candidate genes (Zp2 and Zp3) reveal no contribution to reproductive isolation between bovine species. Chen S, et al. BMC Evol Biol, 2011 Jan 25. PMID 21266067, Free PMC Article
    3. Molecular cloning of bovine zona pellucida glycoproteins ZPA and ZPB and analysis for sperm-binding component of the zona. Yonezawa N, et al. Eur J Biochem, 2001 Jun. PMID 11422390
    4. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. Burkart AD, et al. J Cell Biol, 2012 Apr 2. PMID 22472438, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymorphism of Zp2 and the Zp3 did not show any contribution to reproductive isolation between the bovine species.
      Title: Evolutionary patterns of two major reproduction candidate genes (Zp2 and Zp3) reveal no contribution to reproductive isolation between bovine species.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acrosin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of egg coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in prevention of polyspermy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zona pellucida sperm-binding protein 2
    Names
    zona pellucida glycoprotein 2 (sperm receptor)
    zona pellucida glycoprotein ZP2
    zona pellucida protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173973.2 → NP_776398.1  zona pellucida sperm-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_776398.1

      Status: PROVISIONAL

      Source sequence(s)
      AB042653
      UniProtKB/Swiss-Prot
      Q9BH10
      UniProtKB/TrEMBL
      F1MKT2
      Related
      ENSBTAP00000015289.3, ENSBTAT00000015289.4
      Conserved Domains (2) summary
      smart00241
      Location:367 → 628
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:494 → 629
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19019145..19055627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881143.1 → XP_059737126.1  zona pellucida sperm-binding protein 2 isoform X2

      Related
      ENSBTAP00000070281.2, ENSBTAT00000066749.2

    2. XM_059881144.1 → XP_059737127.1  zona pellucida sperm-binding protein 2 isoform X3

    3. XM_059881142.1 → XP_059737125.1  zona pellucida sperm-binding protein 2 isoform X1

      Related
      ENSBTAP00000059112.2, ENSBTAT00000074062.2

    RNA

    1. XR_009492786.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BH10.1 GenPept UniProtKB/Swiss-Prot:Q9BH10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials