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    MET MET proto-oncogene, receptor tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 280855, updated on 4-Oct-2024

    Summary

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    Official Symbol
    METprovided by VGNC
    Official Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:31394
    See related
    Ensembl:ENSBTAG00000006161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HGFR; c-met
    Orthologs
    human mouse all
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    Genomic context

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    See MET in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (51620793..51735566, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene uncharacterized LOC132345093 Neighboring gene mitochondrial carrier homolog 2-like Neighboring gene caveolin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epidermal growth factor and hepatocyte growth factor receptors collaborate to induce multiple biological responses in bovine mammary epithelial cells. Accornero P, et al. J Dairy Sci, 2009 Aug. PMID 19620648
    2. Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and expression analysis in the mammary gland. Yamaji D, et al. Domest Anim Endocrinol, 2006 Mar. PMID 16207523
    3. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. possible cooperative role of the EGF and HGF pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
      Title: Epidermal growth factor and hepatocyte growth factor receptors collaborate to induce multiple biological responses in bovine mammary epithelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166072

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte growth factor receptor
    Names
    HGF receptor c-Met
    HGF/SF receptor
    SF receptor
    met proto-oncogene (hepatocyte growth factor receptor)
    met proto-oncogene tyrosine kinase
    proto-oncogene c-Met
    scatter factor receptor
    tyrosine-protein kinase Met
    NP_001013017.2
    XP_024846175.1
    XP_024846176.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012999.2 → NP_001013017.2  hepatocyte growth factor receptor precursor

      See identical proteins and their annotated locations for NP_001013017.2

      Status: PROVISIONAL

      Source sequence(s)
      AB112434
      UniProtKB/Swiss-Prot
      A4D7R6, Q769I5
      Related
      ENSBTAP00000008102.5, ENSBTAT00000008102.6
      Conserved Domains (8) summary
      smart00423
      Location:520 → 562
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd00603
      Location:840 → 933
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01180
      Location:564 → 657
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:743 → 838
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1083 → 1344
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:1079 → 1338
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:658 → 741
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:25 → 517
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51620793..51735566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990408.2 → XP_024846176.1  hepatocyte growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NAI5
      Related
      ENSBTAP00000068286.1, ENSBTAT00000086401.2
      Conserved Domains (7) summary
      smart00423
      Location:520 → 562
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd00603
      Location:840 → 933
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01180
      Location:564 → 657
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:743 → 838
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1036 → 1297
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15674
      Location:658 → 741
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:25 → 517
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. XM_024990407.2 → XP_024846175.1  hepatocyte growth factor receptor isoform X1

      UniProtKB/TrEMBL
      Z4YHD9
      Conserved Domains (7) summary
      smart00423
      Location:520 → 562
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd00603
      Location:840 → 933
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01180
      Location:564 → 657
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:743 → 838
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1083 → 1344
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15674
      Location:658 → 741
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:25 → 517
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q769I5.1 GenPept UniProtKB/Swiss-Prot:Q769I5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials