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    Fkbp9 FK506 binding protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 27055, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fkbp9provided by MGI
    Official Full Name
    FK506 binding protein 9provided by MGI
    Primary source
    MGI:MGI:1350921
    See related
    Ensembl:ENSMUSG00000029781 AllianceGenome:MGI:1350921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKBP-9; FKBP60; FKBP63; FKBP-63; FKBP65RS; 1810014L23
    Summary
    Enables calcium ion binding activity. Involved in protein folding. Located in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; incisor; respiratory system; and skeleton. Orthologous to human FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 82.0), bladder adult (RPKM 56.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fkbp9 in Genome Data Viewer
    Location:
    6 B3; 6 27.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56809044..56856345)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56832059..56879360)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E679 Neighboring gene AVL9 cell migration associated Neighboring gene STARR-seq mESC enhancer starr_15991 Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4829 Neighboring gene predicted gene 10209 Neighboring gene STARR-seq mESC enhancer starr_15993 Neighboring gene STARR-seq mESC enhancer starr_15995 Neighboring gene 5'-nucleotidase, cytosolic III Neighboring gene predicted gene, 53332 Neighboring gene STARR-positive B cell enhancer ABC_E8830 Neighboring gene STARR-seq mESC enhancer starr_15996 Neighboring gene vomeronasal 1 receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family. Jo D, et al. Mol Cells, 2001 Oct 31. PMID 11710534
    2. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Shadidy M, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524204
    3. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Lepourcelet M, et al. Development, 2005 Jan. PMID 15604097
    4. Hepatic lipase maturation: a partial proteome of interacting factors. Doolittle MH, et al. J Lipid Res, 2009 Jun. PMID 19136429, Free PMC Article
    5. Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Kawaguchi A, et al. Development, 2008 Sep. PMID 18725516

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.
      Title: Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP9
    Names
    63 kDa FK506-binding protein
    63 kDa FKBP
    PPIase FKBP9
    rotamase
    NP_036186.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012056.2 → NP_036186.2  peptidyl-prolyl cis-trans isomerase FKBP9 precursor

      See identical proteins and their annotated locations for NP_036186.2

      Status: VALIDATED

      Source sequence(s)
      AK007499, BB794531, BC043129
      Consensus CDS
      CCDS39494.1
      UniProtKB/Swiss-Prot
      Q80ZZ6, Q8R386, Q9CVM0, Q9JHX5, Q9Z247
      Related
      ENSMUSP00000031795.8, ENSMUST00000031795.8
      Conserved Domains (3) summary
      cd00051
      Location:497 → 558
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:47 → 139
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:495 → 559
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      56809044..56856345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z247.1 GenPept UniProtKB/Swiss-Prot:Q9Z247

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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