Stk32a serine/threonine kinase 32A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk32aprovided by MGI
Official Full Name: serine/threonine kinase 32Aprovided by MGI
Primary source: MGI:MGI:2442403
See related: Ensembl:ENSMUSG00000039954 AllianceGenome:MGI:2442403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: YANK1; A930015B13Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in plasma membrane. Orthologous to human STK32A (serine/threonine kinase 32A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 3.3), CNS E18 (RPKM 1.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 23.17 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (43340762..43450546)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (43207697..43317481)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.
Title: The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.
Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase 32A

NP_848864.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178749.3 → NP_848864.1 serine/threonine-protein kinase 32A

See identical proteins and their annotated locations for NP_848864.1

Status: VALIDATED

Source sequence(s)

AK036266

Consensus CDS

CCDS29218.1

UniProtKB/Swiss-Prot

Q7TPQ4, Q8BGW6

Related

ENSMUSP00000038471.5, ENSMUST00000045477.6

Conserved Domains (2) summary

smart00220
Location:23 → 270

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05578
Location:22 → 281

STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1