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    Fzd9 frizzled class receptor 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266608, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Fzd9provided by RGD
    Official Full Name
    frizzled class receptor 9provided by RGD
    Primary source
    RGD:628817
    See related
    EnsemblRapid:ENSRNOG00000001452 AllianceGenome:RGD:628817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rFz9
    Summary
    Enables Wnt-activated receptor activity. Involved in Wnt signaling pathway; postsynapse organization; and regulation of postsynaptic cytosolic calcium ion concentration. Located in plasma membrane. Is active in glutamatergic synapse and postsynapse. Orthologous to human FZD9 (frizzled class receptor 9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Fzd9 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27063640..27065954)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21427084..21429398)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24473981..24476295)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095916 Neighboring gene uncharacterized LOC134481280 Neighboring gene bromodomain adjacent to zinc finger domain, 1B Neighboring gene 5S ribosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A human neurodevelopmental model for Williams syndrome. Chailangkarn T, et al. Nature, 2016 Aug 18. PMID 27509850, Free PMC Article
    2. Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Zhao C, et al. Development, 2005 Jun. PMID 15930120
    3. Frizzled 9 knock-out mice have abnormal B-cell development. Ranheim EA, et al. Blood, 2005 Mar 15. PMID 15572594
    4. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C, et al. Differentiation, 2008 Sep. PMID 18177422, Free PMC Article
    5. Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. Ramírez VT, et al. J Biol Chem, 2016 Sep 2. PMID 27402827, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction.
      Title: Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction.
    2. findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
      Title: Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation.
    3. functions as a Wnt receptor, and is acivated by it
      Title: Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bone regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of skeletal muscle acetylcholine-gated channel clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of skeletal muscle acetylcholine-gated channel clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of skeletal muscle acetylcholine-gated channel clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of skeletal muscle acetylcholine-gated channel clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frizzled-9
    Names
    Frizzled-like protein 9
    frizzled family receptor 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153305.1 → NP_695217.1  frizzled-9 precursor

      See identical proteins and their annotated locations for NP_695217.1

      Status: PROVISIONAL

      Source sequence(s)
      AF455054
      UniProtKB/Swiss-Prot
      Q8K4C8
      Related
      ENSRNOP00000102705.1, ENSRNOT00000170154.1
      Conserved Domains (2) summary
      cd07463
      Location:36 → 162
      CRD_FZ9; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor
      cd15036
      Location:222 → 543
      7tmF_FZD9; class F frizzled subfamily 9, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      27063640..27065954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4C8.1 GenPept UniProtKB/Swiss-Prot:Q8K4C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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