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    sgo1 shugoshin Sgo1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541326, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sgo1
    Official Full Name
    shugoshin Sgo1
    Primary source
    PomBase:SPBP35G2.03c
    Locus tag
    SPOM_SPBP35G2.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sgo1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (967736..968767, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene poteasome interacting protein Txc1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Shugoshin function during fission-yeast meiosis. Vaur S, et al. Curr Biol, 2005 Dec 20. PMID 16360688
    2. Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Rabitsch KP, et al. Curr Biol, 2004 Feb 17. PMID 14972679
    3. Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. Gregan J, et al. Curr Biol, 2005 Sep 20. PMID 16169489
    4. Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I. Hirose Y, et al. PLoS Genet, 2011 Mar. PMID 21423721, Free PMC Article
    5. Hierarchical Regulation of Centromeric Cohesion Protection by Meikin and Shugoshin during Meiosis I. Miyazaki S, et al. Cold Spring Harb Symp Quant Biol, 2017. PMID 29196561

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. balance between Rec8 phosphorylation and its dephosphorylation by Sgo1-PP2A regulates the step-wise loss of chromosomal cohesion in meiosis
      Title: Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
    2. findings show that Bub1 phosphorylates the conserved serine 121 of histone H2A; Bub1 kinase creates a mark for shugoshin localization and the correct partitioning of chromosomes
      Title: Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
    3. the heterochromatin protein Swi6 associates directly with meiosis-specific shugoshin Sgo1, a protector of cohesin at centromeres
      Title: Heterochromatin links to centromeric protection by recruiting shugoshin.
    4. Sgo1-mediated protection of centromere cohesion might be regulated by the mode of kinetochore attachment during meiosis.
      Title: Control of Shugoshin function during fission-yeast meiosis.
    5. Sgo1 is required for retention of centromeric sister-chromatid cohesion after anaphase I. [sgo1]
      Title: Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid segregation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of inner kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shugoshin Sgo1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      967736..968767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021285.2 → NP_595378.1  shugoshin Sgo1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595378.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7A0
      Conserved Domains (2) summary
      pfam07557
      Location:277 → 302
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:21 → 65
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials