Dcc DCC netrin 1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dccprovided by RGD
Official Full Name: DCC netrin 1 receptorprovided by RGD
Primary source: RGD:2492
See related: Ensembl:ENSRNOG00000033099 AllianceGenome:RGD:2492
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; and response to amphetamine. Located in growth cone membrane and membrane raft. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 45.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1-q12.2

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (67144272..68248159, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (64868987..65972783, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (66518213..67629801, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
Title: FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
miRs let-7 and miR-9 are involved in regulating neuron pathfinding and extend our understanding of the regulatory pathways active during peripheral nerve regeneration
Title: The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration.
DCC activation of Src is required for NMDAR-dependent long-term potentiation and certain forms of learning and memory.
Title: DCC expression by neurons regulates synaptic plasticity in the adult brain.
Trio(Y2622) phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth.
Title: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth.
Treadmill exercise has beneficial effects via involvement of netrin-1 and its receptors DCC and Unc5B in neuronal and vascular activities in brain-ischemic rats.
Title: Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia.
DCC have Prominent Expression in Adult Schwann cells.
Title: Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2.
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
Title: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
DCC seen in lateral/apical sides of newly differentiating/secretory ameloblasts. DCC localized only in apical side of mature-stage ameloblasts not in lateral side. DCC expressed in differentiating ameloblasts, suggesting a crucial role in amelogenesis.
Title: Expression of DCC in differentiating ameloblasts from developing tooth germs in rats.
Netrin-1 attracts mossy fibres via DCC under control conditions and repels them via UNC5A under hyperexcitable conditions.
Title: The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
Data report that Bcl11A downregulates axon branching, and that the expression of DCC and MAP1b, two molecules involved in direction and branching of axon outgrowth, is controlled by Bcl11A-L.
Title: Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE118490 (e-PCR)
- UniSTS:248832

d18rat85 (e-PCR)
- UniSTS:121346

d18rat86 (e-PCR)
- UniSTS:121347

AW520939 (e-PCR)
- UniSTS:249365

Dcc (e-PCR), detects polymorphism
- UniSTS:471088

AU026234 (e-PCR)
- UniSTS:114481

AU048327 (e-PCR)
- UniSTS:109645

Dcc (e-PCR), detects polymorphism
- UniSTS:526935

AU048796 (e-PCR)
- UniSTS:145246

D18Rat124 (e-PCR), detects polymorphism
- UniSTS:226919

BE105775 (e-PCR)
- UniSTS:245907

D1S3690 (e-PCR)
- UniSTS:474268

d18mgh3 (e-PCR)
- UniSTS:120222

GDB:201899 (e-PCR)
- UniSTS:156083

D18Chm59 (e-PCR)
- UniSTS:518347

BE106373 (e-PCR)
- UniSTS:246242

D18Chm58 (e-PCR)
- UniSTS:518382

d18rat54 (e-PCR)
- UniSTS:121328

AU027865 (e-PCR)
- UniSTS:112889

BE107748 (e-PCR)
- UniSTS:247035

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables netrin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axon guidance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dorsal/ventral axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral axon guidance	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord ventral commissure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord ventral commissure morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: netrin receptor DCC

Names: colorectal tumor suppressor; deleted in colorectal carcinoma; putative colorectal tumor suppressor; tumor suppressor protein DCC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012841.2 → NP_036973.1 netrin receptor DCC precursor

See identical proteins and their annotated locations for NP_036973.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q63155

UniProtKB/TrEMBL

F1LRN5

Related

ENSRNOP00000063072.4, ENSRNOT00000064947.4

Conserved Domains (8) summary

cd05722
Location:42 → 136

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:153 → 219

IGc2; Immunoglobulin C-2 Type

smart00060
Location:726 → 805

FN3; Fibronectin type 3 domain

smart00410
Location:147 → 224

IG_like; Immunoglobulin like

cd00063
Location:528 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:241 → 327

I-set; Immunoglobulin I-set domain

pfam06583
Location:1148 → 1443

Neogenin_C; Neogenin C-terminus

cl11960
Location:347 → 417

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

67144272..68248159 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772087.4 → XP_008770309.2 netrin receptor DCC isoform X3

UniProtKB/TrEMBL

A0A8I6ATC8, F1LRN5

Related

ENSRNOP00000096451.1
XM_063277120.1 → XP_063133190.1 netrin receptor DCC isoform X5

UniProtKB/TrEMBL

F1LRN5
XM_063277119.1 → XP_063133189.1 netrin receptor DCC isoform X4

UniProtKB/TrEMBL

F1LRN5
XM_063277122.1 → XP_063133192.1 netrin receptor DCC isoform X7

UniProtKB/TrEMBL

F1LRN5
XM_063277121.1 → XP_063133191.1 netrin receptor DCC isoform X6

UniProtKB/TrEMBL

F1LRN5
XM_063277118.1 → XP_063133188.1 netrin receptor DCC isoform X2

UniProtKB/TrEMBL

F1LRN5
XM_039096588.2 → XP_038952516.2 netrin receptor DCC isoform X1

UniProtKB/TrEMBL

F1LRN5
XM_039096590.2 → XP_038952518.1 netrin receptor DCC isoform X8

Conserved Domains (3) summary

smart00060
Location:230 → 309

FN3; Fibronectin type 3 domain

cd00063
Location:32 → 121

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06583
Location:652 → 949

Neogenin_C; Neogenin C-terminus