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    Mas1 MAS1 proto-oncogene, G protein-coupled receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25153, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Mas1provided by RGD
    Official Full Name
    MAS1 proto-oncogene, G protein-coupled receptorprovided by RGD
    Primary source
    RGD:3049
    See related
    EnsemblRapid:ENSRNOG00000014971 AllianceGenome:RGD:3049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgra; c-mas
    Summary
    Predicted to enable angiotensin receptor activity and peptide binding activity. Involved in several processes, including hippocampus development; positive regulation of DNA replication; and regulation of phosphate metabolic process. Located in cell surface. Used to study glaucoma and hypertension. Biomarker of congestive heart failure; dilated cardiomyopathy; and primary biliary cholangitis. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 15.2), Heart (RPKM 5.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mas1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50428064..50459537)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47879956..47911500)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48076761..48108218)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene MAS1 proto-oncogene like, G protein-coupled receptor Neighboring gene uncharacterized LOC120099123 Neighboring gene uncharacterized LOC134482693 Neighboring gene uncharacterized LOC134482699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury. Zhou G, et al. Int J Biol Macromol, 2022 May 15. PMID 35247425
    2. Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension. Savoia C, et al. Hypertension, 2020 Dec. PMID 33070664
    3. Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor. Gaidarov I, et al. Cell Signal, 2018 Oct. PMID 29928987
    4. Intrarenal Mas and AT(1) receptors play a role in mediating the excretory actions of renal interstitial angiotensin-(1-7) infusion in anaesthetized rats. O'Neill J, et al. Exp Physiol, 2017 Dec 1. PMID 28940861
    5. Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium. Hoffmann BR, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28082260, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
      Title: G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
    2. Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
      Title: Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
    3. Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
      Title: Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
    4. Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
      Title: Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
    5. Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
      Title: Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
    6. TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
      Title: TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
    7. Data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling in the skeletal muscle.
      Title: Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.
    8. Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor.
      Title: Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
    9. Small molecule ligands modulate numerous G protein-dependent and independent pathways through MAS1.
      Title: Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
    10. Renal AT1 receptor activation, as well as Mas receptor activation, plays an essential role in mediating Ang-(1-7)-induced natriuresis and diuresis.
      Title: Intrarenal Mas and AT(1) receptors play a role in mediating the excretory actions of renal interstitial angiotensin-(1-7) infusion in anaesthetized rats.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables angiotensin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables angiotensin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proto-oncogene Mas
    Names
    MAS proto-oncogene
    MAS1 oncogene
    Mas-related G protein-coupled receptor a
    angiotensin-(1-7) receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012757.2 → NP_036889.1  proto-oncogene Mas

      See identical proteins and their annotated locations for NP_036889.1

      Status: VALIDATED

      Source sequence(s)
      BC078884
      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Conserved Domains (1) summary
      cd15110
      Location:32 → 306
      7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50428064..50459537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281329.1 → XP_063137399.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000020100.4, ENSRNOT00000020100.7

    2. XM_039101409.2 → XP_038957337.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000097396.1, ENSRNOT00000104217.2
      Conserved Domains (1) summary
      cd15110
      Location:32 → 306
      7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_063281319.1 → XP_063137389.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4

    4. XM_063281307.1 → XP_063137377.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4

    5. XM_006227860.5 → XP_006227922.1  proto-oncogene Mas isoform X1

      See identical proteins and their annotated locations for XP_006227922.1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000104659.1, ENSRNOT00000132244.1
      Conserved Domains (1) summary
      cd15110
      Location:32 → 306
      7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_039101408.2 → XP_038957336.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000103225.1, ENSRNOT00000164553.1
      Conserved Domains (1) summary
      cd15110
      Location:32 → 306
      7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_063281318.1 → XP_063137388.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4

    8. XM_039101416.2 → XP_038957344.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000100641.1, ENSRNOT00000127520.1
      Conserved Domains (1) summary
      cd15110
      Location:32 → 306
      7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. XM_063281312.1 → XP_063137382.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12526.1 GenPept UniProtKB/Swiss-Prot:P12526

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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