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    Hk3 hexokinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25060, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hk3provided by RGD
    Official Full Name
    hexokinase 3provided by RGD
    Primary source
    RGD:2798
    See related
    EnsemblRapid:ENSRNOG00000026235 AllianceGenome:RGD:2798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RNU73859
    Summary
    Enables enzyme binding activity; hexokinase activity; and hormone binding activity. Involved in fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Part of protein-containing complex. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 24.4), Spleen (RPKM 22.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hk3 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9602119..9620038)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9596950..9614847)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10134726..10152976)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene unc-5 netrin receptor A Neighboring gene uncharacterized LOC120097834 Neighboring gene tetraspanin 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords. Lin YH, et al. Neurochem Int, 2018 Feb. PMID 29196144
    2. Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA. Schwab DA, et al. Arch Biochem Biophys, 1991 Mar. PMID 1897938
    3. Regulation and cytoprotective role of hexokinase III. Wyatt E, et al. PLoS One, 2010 Nov 3. PMID 21072205, Free PMC Article
    4. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. Palma F, et al. Mol Cell Biochem, 1996 Feb 9. PMID 8717435
    5. A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198. Chan YL, et al. J Biol Chem, 1994 Feb 25. PMID 8119894

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HK3 may be involved in the pathologic process ofspinal cord injury by promoting glucose metabolism.
      Title: Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hormone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hexokinase-3
    Names
    HK III
    hexokinase 3 (white cell)
    hexokinase type III
    hexokinase-C
    NP_071515.1
    XP_006253665.1
    XP_038951301.1
    XP_063132145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022179.2 → NP_071515.1  hexokinase-3

      See identical proteins and their annotated locations for NP_071515.1

      Status: PROVISIONAL

      Source sequence(s)
      U73859
      UniProtKB/Swiss-Prot
      P27926, Q497A1
      UniProtKB/TrEMBL
      A0A0G2JTY2
      Related
      ENSRNOP00000031587.1, ENSRNOT00000031935.4
      Conserved Domains (3) summary
      PTZ00107
      Location:23 → 474
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:482 → 674
      Hexokinase_1
      pfam03727
      Location:680 → 912
      Hexokinase_2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9602119..9620038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253603.5 → XP_006253665.1  hexokinase-3 isoform X1

      See identical proteins and their annotated locations for XP_006253665.1

      UniProtKB/TrEMBL
      A0A0G2JST6, A0A0G2JTY2, A6KAV7
      Conserved Domains (3) summary
      PTZ00107
      Location:23 → 474
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:482 → 674
      Hexokinase_1
      pfam03727
      Location:680 → 914
      Hexokinase_2

    2. XM_063276075.1 → XP_063132145.1  hexokinase-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JST6, A6KAV7

    3. XM_039095373.2 → XP_038951301.1  hexokinase-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JST6, A0A0G2JTY2, A6KAV7
      Conserved Domains (3) summary
      PTZ00107
      Location:23 → 474
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:482 → 674
      Hexokinase_1
      pfam03727
      Location:680 → 914
      Hexokinase_2

    RNA

    1. XR_005495237.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27926.1 GenPept UniProtKB/Swiss-Prot:P27926

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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