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    Chm CHM Rab escort protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24942, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Chmprovided by RGD
    Official Full Name
    CHM Rab escort proteinprovided by RGD
    Primary source
    RGD:2340
    See related
    EnsemblRapid:ENSRNOG00000000161 AllianceGenome:RGD:2340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in choroideremia. Orthologous to human CHM (CHM Rab escort protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 114.1), Kidney (RPKM 95.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chm in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (82395463..82554249, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (78203200..78361996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (84666900..84821775, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932431L22 gene like Neighboring gene uncharacterized LOC134484138 Neighboring gene uncharacterized LOC134484103 Neighboring gene tubulin, gamma 1, pseudogene 1 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 361 Neighboring gene U4 spliceosomal RNA Neighboring gene dachshund family transcription factor 2 Neighboring gene small nucleolar RNA SNORA31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Seabra MC, et al. Cell, 1992 Sep 18. PMID 1525821
    2. Cloning, mapping and characterization of the human RAB27A gene. Tolmachova T, et al. Gene, 1999 Oct 18. PMID 10571040
    3. cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Andres DA, et al. Cell, 1993 Jun 18. PMID 8513495
    4. [Autoregulation of cerebral blood flow]. Zderkiewicz E. Pol Tyg Lek, 1978 Jul 17. PMID 704419
    5. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RabGGTase has evolved from a GGTase-I-like molecule that 'learned' to interact with a recycling factor (GDI) that, in turn, eventually gave rise to REP1.
      Title: Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein geranylgeranylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein geranylgeranylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein geranylgeranylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rab-protein geranylgeranyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Rab-protein geranylgeranyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rab proteins geranylgeranyltransferase component A 1
    Names
    CHM, Rab escort protein 1
    REP-1
    choroideraemia protein homolog
    choroideremia (Rab escort protein 1)
    choroideremia protein homolog
    choroidermia
    rab escort protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433732.1 → NP_001420661.1  rab proteins geranylgeranyltransferase component A 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    2. NM_017067.2 → NP_058763.2  rab proteins geranylgeranyltransferase component A 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      Related
      ENSRNOP00000000174.7, ENSRNOT00000000174.9

    RNA

    1. NR_197594.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      82395463..82554249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099489.2 → XP_038955417.1  rab proteins geranylgeranyltransferase component A 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG68
      Conserved Domains (1) summary
      cl21454
      Location:149 → 457
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_005497922.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37727.1 GenPept UniProtKB/Swiss-Prot:P37727

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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