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    Odc1 ornithine decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24609, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Odc1provided by RGD
    Official Full Name
    ornithine decarboxylase 1provided by RGD
    Primary source
    RGD:3227
    See related
    EnsemblRapid:ENSRNOG00000005424 AllianceGenome:RGD:3227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Odc
    Summary
    Enables ornithine decarboxylase activity. Involved in putrescine biosynthetic process. Located in perinuclear region of cytoplasm. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 810.1), Thymus (RPKM 444.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Odc1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46058439..46065148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40329831..40336444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42852529..42859142)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene craniofacial development protein 1 like 1 Neighboring gene proteasome activator subunit 3, pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 80B Neighboring gene uncharacterized LOC134479118 Neighboring gene uncharacterized LOC134479347

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats. Hayashi T, et al. Hypertens Res, 2002 Sep. PMID 12452334
    2. Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region. Manzella JM, et al. J Biol Chem, 1990 Jul 15. PMID 2365701
    3. Immunocytochemical detection of ornithine decarboxylase. Schipper RG, et al. J Histochem Cytochem, 1999 Nov. PMID 10544213
    4. Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene. Wen L, et al. J Biol Chem, 1989 May 25. PMID 2722815
    5. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors? Deng A, et al. Diabetes, 2003 May. PMID 12716758

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicated that overexpression of ODC gene promotes the proliferation while suppressing apoptosis of fibroblast-like synoviocytes in rats with rheumatoid arthritis.
      Title: Effects of lentivirus-mediated ornithine decarboxylase gene on the proliferation and apoptosis of fibroblast-like synoviocytes in rats with arthritis.
    2. These results suggest that IPC upregulates the Ornithine decarboxylase/polyamine system and mediates preconditioning cardioprotection.
      Title: Akt and Erk1/2 activate the ornithine decarboxylase/polyamine system in cardioprotective ischemic preconditioning in rats: the role of mitochondrial permeability transition pores.
    3. The modulation of ODC activity by AMPK represents a mechanism that may contribute to control cell growth processes.
      Title: Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts.
    4. effect of deep hypothermia on the ODC activity
      Title: The effect of hypothermia on the ornithine decarboxylase activity in tissues of rats.
    5. Overexpression of ornithine decarboxylase increases myogenic potential of rat myoblasts.
      Title: Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts.
    6. Results show that transglutaminase-catalyzed polyamination of rhoA regulates its activity, and that ornithine decarboxylase influences the intracellular distribution of rhoA.
      Title: Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination.
    7. The tumor-like proliferation of synoviocytes from AA rat joint might be related to the increased mRNAs of C-myc and ODC genes.
      Title: [The study on the relationship between the tumor-like proliferation of synoviocytes and the expression of c-myc and ODC genes in adjuvant arthritis rats].
    8. ODC is necessary for hyperresponsiveness of the proximal tubule to dietary salt and for the paradoxical effect of dietary salt on GFR in early diabetes
      Title: Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.
    9. The aim of this study was to investigate the role of TG2, ODC, and their products in regenerating rat liver after partial hepatectomy by using retinoic acid.
      Title: Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration.
    10. Corticosterone decreases ODC mRNA and enzyme protein both in the intact liver and the regenerating liver.
      Title: Regulatory effects of corticosterone on ornithine decarboxylase activity during liver regeneration in rats.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ornithine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process from ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine biosynthetic process from ornithine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase
    Names
    Ornitine decarboxylase
    NP_001289012.1
    NP_036747.1
    XP_006239969.1
    XP_006239970.1
    XP_017449519.1
    XP_063117614.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302083.1 → NP_001289012.1  ornithine decarboxylase

      See identical proteins and their annotated locations for NP_001289012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has two alternate splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DV728774, FQ151473, J04791, M16982
      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9
      Conserved Domains (2) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 408
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    2. NM_012615.3 → NP_036747.1  ornithine decarboxylase

      See identical proteins and their annotated locations for NP_036747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC078882, DV728774, FQ151473, M16982
      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9
      Conserved Domains (2) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 408
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      46058439..46065148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594030.2 → XP_017449519.1  ornithine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9
      Related
      ENSRNOP00000007259.2, ENSRNOT00000007259.6
      Conserved Domains (2) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 408
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    2. XM_006239907.5 → XP_006239969.1  ornithine decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006239969.1

      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9
      Conserved Domains (2) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 408
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    3. XM_063261544.1 → XP_063117614.1  ornithine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9

    4. XM_006239908.5 → XP_006239970.1  ornithine decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006239970.1

      UniProtKB/Swiss-Prot
      P09057
      UniProtKB/TrEMBL
      A6HAU9
      Conserved Domains (2) summary
      cd00622
      Location:37 → 408
      PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
      COG0019
      Location:40 → 408
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09057.1 GenPept UniProtKB/Swiss-Prot:P09057

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