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    Adgrf5 adhesion G protein-coupled receptor F5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245977, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adgrf5provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor F5provided by RGD
    Primary source
    RGD:621679
    See related
    EnsemblRapid:ENSRNOG00000011154 AllianceGenome:RGD:621679
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr116; Gprhep; Ig-Hepta
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy reserve metabolic process; and fat cell differentiation. Predicted to act upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Predicted to be located in apical part of cell and cell surface. Predicted to be active in cytoplasmic vesicle. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1414.6), Heart (RPKM 382.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrf5 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (25014861..25128045, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (17517596..17624107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (20091121..20195706, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094640 Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene uncharacterized LOC120094840

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. Abe J, et al. J Biol Chem, 1999 Jul 9. PMID 10391944
    2. Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. Nie T, et al. FEBS Lett, 2012 Oct 19. PMID 22971422
    3. Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site. Abe J, et al. J Biol Chem, 2002 Jun 28. PMID 11973329
    4. Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Yang MY, et al. Cell Rep, 2013 May 30. PMID 23684610, Free PMC Article
    5. Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation. Ariestanti DM, et al. J Biol Chem, 2015 Apr 24. PMID 25778400, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pharyngeal arch artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pharyngeal arch artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor F5
    Names
    G protein-coupled hepta-helical receptor Ig-Hepta
    G-protein coupled hepta-helical receptor Ig-hepta
    G-protein coupled receptor 116
    probable G-protein coupled receptor 116

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139110.2 → NP_620810.1  adhesion G protein-coupled receptor F5 precursor

      See identical proteins and their annotated locations for NP_620810.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9WVT0
      UniProtKB/TrEMBL
      A6JJ39
      Related
      ENSRNOP00000015223.1, ENSRNOT00000015223.4
      Conserved Domains (6) summary
      smart00408
      Location:283 → 351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:475 → 560
      IG_like; Immunoglobulin like
      pfam00047
      Location:473 → 550
      ig; Immunoglobulin domain
      pfam01390
      Location:166 → 252
      SEA; SEA domain
      pfam01825
      Location:952 → 999
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:1014 → 1265
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      25014861..25128045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266632.1 → XP_063122702.1  adhesion G protein-coupled receptor F5 isoform X6

    2. XM_063266631.1 → XP_063122701.1  adhesion G protein-coupled receptor F5 isoform X6

    3. XM_008766833.4 → XP_008765055.1  adhesion G protein-coupled receptor F5 isoform X6

      See identical proteins and their annotated locations for XP_008765055.1

      Related
      ENSRNOP00000102120.1, ENSRNOT00000135806.1
      Conserved Domains (6) summary
      smart00410
      Location:537 → 622
      IG_like; Immunoglobulin like
      pfam00047
      Location:535 → 612
      ig; Immunoglobulin domain
      pfam01390
      Location:166 → 252
      SEA; SEA domain
      pfam01825
      Location:1014 → 1061
      GPS; GPCR proteolysis site, GPS, motif
      cl11960
      Location:283 → 351
      Ig; Immunoglobulin domain
      cl21561
      Location:1076 → 1327
      7tm_4; Olfactory receptor

    4. XM_008766832.4 → XP_008765054.1  adhesion G protein-coupled receptor F5 isoform X6

      See identical proteins and their annotated locations for XP_008765054.1

      Conserved Domains (6) summary
      smart00410
      Location:537 → 622
      IG_like; Immunoglobulin like
      pfam00047
      Location:535 → 612
      ig; Immunoglobulin domain
      pfam01390
      Location:166 → 252
      SEA; SEA domain
      pfam01825
      Location:1014 → 1061
      GPS; GPCR proteolysis site, GPS, motif
      cl11960
      Location:283 → 351
      Ig; Immunoglobulin domain
      cl21561
      Location:1076 → 1327
      7tm_4; Olfactory receptor

    5. XM_039083014.2 → XP_038938942.1  adhesion G protein-coupled receptor F5 isoform X5

      Conserved Domains (7) summary
      smart00409
      Location:298 → 372
      IG; Immunoglobulin
      pfam01390
      Location:181 → 273
      SEA; SEA domain
      pfam01825
      Location:1029 → 1076
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:548 → 621
      Ig_3; Immunoglobulin domain
      cd00096
      Location:548 → 551
      Ig; Ig strand A [structural motif]
      cd14964
      Location:1091 → 1116
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:1090 → 1363
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_039083012.1 → XP_038938940.1  adhesion G protein-coupled receptor F5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZZ0
      Related
      ENSRNOP00000071238.2, ENSRNOT00000082904.3
      Conserved Domains (7) summary
      smart00409
      Location:283 → 357
      IG; Immunoglobulin
      pfam01390
      Location:166 → 258
      SEA; SEA domain
      pfam01825
      Location:992 → 1039
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:511 → 584
      Ig_3; Immunoglobulin domain
      cd00096
      Location:511 → 514
      Ig; Ig strand A [structural motif]
      cd14964
      Location:1054 → 1079
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:1053 → 1326
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_039083013.1 → XP_038938941.1  adhesion G protein-coupled receptor F5 isoform X4

      Conserved Domains (7) summary
      smart00409
      Location:283 → 357
      IG; Immunoglobulin
      pfam01390
      Location:166 → 258
      SEA; SEA domain
      pfam01825
      Location:974 → 1021
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:493 → 566
      Ig_3; Immunoglobulin domain
      cd00096
      Location:493 → 496
      Ig; Ig strand A [structural motif]
      cd14964
      Location:1036 → 1061
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:1035 → 1308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_063266630.1 → XP_063122700.1  adhesion G protein-coupled receptor F5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AR34
      Related
      ENSRNOP00000096657.1, ENSRNOT00000118179.2

    9. XM_008766834.4 → XP_008765056.1  adhesion G protein-coupled receptor F5 isoform X1

      Conserved Domains (6) summary
      smart00410
      Location:537 → 622
      IG_like; Immunoglobulin like
      pfam00047
      Location:535 → 612
      ig; Immunoglobulin domain
      pfam01390
      Location:166 → 252
      SEA; SEA domain
      pfam01825
      Location:1014 → 1061
      GPS; GPCR proteolysis site, GPS, motif
      cl11960
      Location:283 → 351
      Ig; Immunoglobulin domain
      cl21561
      Location:1076 → 1327
      7tm_4; Olfactory receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVT0.1 GenPept UniProtKB/Swiss-Prot:Q9WVT0

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