Zscan4c zinc finger and SCAN domain containing 4C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zscan4cprovided by MGI
Official Full Name: zinc finger and SCAN domain containing 4Cprovided by MGI
Primary source: MGI:MGI:2685243
See related: Ensembl:ENSMUSG00000054272 AllianceGenome:MGI:2685243
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm397; Zscan4d; XM_142517
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of mitotic recombination; regulation of transcription by RNA polymerase II; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in 1-cell stage embryo; 2-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human ZSCAN4 (zinc finger and SCAN domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A1; 7 6.77 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (10739672..10744474)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (11005745..11010547)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zscan4c activates endogenous retrovirus transposable elements and cleavage embryo genes.
Title: Zscan4c activates endogenous retrovirus MERVL and cleavage embryo genes.
Data show that zinc finger protein 42 (Rex1) and zinc finger and SCAN domain containing 4D/4C (Zscan4D/4C) correlate with the cell-cycle length under different mechanisms.
Title: Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells.
this study identified a unique set of facultative heterochromatin regions that respond specifically to Zscan4 expression (tentatively called 'Z4 event-associated heterochromatin, zHC').
Title: Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells.
Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells
Title: Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells.
Zscan4 is involved in telomere maintenance and long-term genomic stability in ES cells
Title: Zscan4 regulates telomere elongation and genomic stability in ES cells.
the importance of Zscan4c in regulation of embryonic stem cell pluripotency
Title: Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of mitotic recombination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic recombination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within telomere maintenance via telomere lengthening	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within telomere maintenance via telomere lengthening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomere lengthening	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger and SCAN domain containing protein 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013765.2 → NP_001013787.1 zinc finger and SCAN domain containing protein 4C

See identical proteins and their annotated locations for NP_001013787.1

Status: PROVISIONAL

Source sequence(s)

AC166368

Consensus CDS

CCDS52012.1

UniProtKB/Swiss-Prot

Q80VJ6

UniProtKB/TrEMBL

A0A1C7CYU6

Related

ENSMUSP00000118506.3, ENSMUST00000131379.4

Conserved Domains (4) summary

sd00017
Location:426 → 446

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:395 → 417

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:438 → 463

zf-H2C2_2; Zinc-finger double domain

cl02605
Location:51 → 117

SCAN; SCAN oligomerization domain