Grm5 glutamate metabotropic receptor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grm5provided by RGD
Official Full Name: glutamate metabotropic receptor 5provided by RGD
Primary source: RGD:2746
See related: EnsemblRapid:ENSRNOG00000016429 AllianceGenome:RGD:2746
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mGluR5; mGlur5
Summary: Enables several functions, including A2A adenosine receptor binding activity; protein tyrosine kinase activator activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; and regulation of signal transduction. Located in astrocyte projection; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 246.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (150722711..151297585)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (141310069..141884980)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (151207846..151785038)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mGluR5-mediated Arc activation protects against experimental traumatic brain injury in rats.
Title: The mGluR5-mediated Arc activation protects against experimental traumatic brain injury in rats.
Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
Title: Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats.
Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Genetic ablation of metabotropic glutamate receptor 5 in rats results in an autism-like behavioral phenotype.
Title: Genetic ablation of metabotropic glutamate receptor 5 in rats results in an autism-like behavioral phenotype.
Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage.
Title: Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage.
Upregulated mGluR5 induces ER stress and DNA damage by regulating the NMDA receptor subunit NR2B.
Title: Upregulated mGluR5 induces ER stress and DNA damage by regulating the NMDA receptor subunit NR2B.
IP3R-mediated activation of BK channels contributes to mGluR5-induced protection against spinal cord ischemia-reperfusion injury.
Title: IP(3)R-mediated activation of BK channels contributes to mGluR5-induced protection against spinal cord ischemia-reperfusion injury.
Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
Title: Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model.
Title: Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model.
mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving.
Title: mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving.

Submit: New GeneRIF Correction See all GeneRIFs (217)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF399922 (e-PCR)
- UniSTS:247861

RH144288 (e-PCR)
- UniSTS:233533

SGC30871 (e-PCR)
- UniSTS:33861

D1Hmgc13 (e-PCR)
- UniSTS:526181

AI850523 (e-PCR)
- UniSTS:165537

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A2A adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	TAS Traceable Author Statement more info	PubMed
enables PLC activating G protein-coupled glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in desensitization of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metabotropic glutamate receptor 5

Names: glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017012.2 → NP_058708.1 metabotropic glutamate receptor 5 precursor

See identical proteins and their annotated locations for NP_058708.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0H2UHW6, A6I5Y9

Related

ENSRNOP00000040016.3, ENSRNOT00000050639.4

Conserved Domains (5) summary

cd06374
Location:26 → 496

PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor

pfam00003
Location:590 → 823

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:67 → 471

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:507 → 556

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1121 → 1171

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

150722711..151297585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096032.2 → XP_038951960.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

P31424

UniProtKB/TrEMBL

A0A0H2UHN1, B2CZC8

Conserved Domains (5) summary

pfam05109
Location:1013 → 1171

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_017588778.3 → XP_017444267.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

P31424

UniProtKB/TrEMBL

A0A0H2UHN1, B2CZC8

Conserved Domains (5) summary

pfam05109
Location:1013 → 1171

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_006229659.5 → XP_006229721.1 metabotropic glutamate receptor 5 isoform X1

See identical proteins and their annotated locations for XP_006229721.1

UniProtKB/Swiss-Prot

P31424

UniProtKB/TrEMBL

A0A0H2UHN1, B2CZC8

Related

ENSRNOP00000106840.1, ENSRNOT00000157575.1

Conserved Domains (5) summary

pfam05109
Location:1013 → 1171

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_017588781.3 → XP_017444270.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

A0A0H2UHW6, A6I5Y9
XM_063280722.1 → XP_063136792.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

A6I5Y9
XM_017588780.3 → XP_017444269.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

P31424

UniProtKB/TrEMBL

A0A0H2UHN1, B2CZC8

Related

ENSRNOP00000022059.5, ENSRNOT00000022060.7

Conserved Domains (5) summary

pfam05109
Location:1013 → 1171

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_063280720.1 → XP_063136790.1 metabotropic glutamate receptor 5 isoform X2

UniProtKB/TrEMBL

A6I5Y9
XM_017588779.3 → XP_017444268.1 metabotropic glutamate receptor 5 isoform X1

UniProtKB/Swiss-Prot

P31424

UniProtKB/TrEMBL

A0A0H2UHN1, B2CZC8

Conserved Domains (5) summary

pfam05109
Location:1013 → 1171

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd15450
Location:577 → 826

7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:26 → 496

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:507 → 557

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1154 → 1203

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor