Ces1c carboxylesterase 1C [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ces1cprovided by RGD
Full Name: carboxylesterase 1Cprovided by RGD
Primary source: RGD:2571
See related: EnsemblRapid:ENSRNOG00000069004 AllianceGenome:RGD:2571
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Es1; Es2
Summary: Enables carboxylesterase activity and protein homodimerization activity. Predicted to be involved in lipid catabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1) and CES1P1 (carboxylesterase 1 pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1471.6) See more
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Genomic context

Location:: 19p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (30099383..30128531)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13926401..13955527)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (15294524..15335005)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Es2 was induced by dexamethasone in liver microsomes and identified in plasma.
Title: Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carboxylesterase 1C

Names: E1; ES-THET; Esterase 2 member of carboxylesterase-cluster 1; NREH; REH; carboxyesterase ES-1; esterase 1; esterase 2, member of carboxylesterase-cluster 1; esterase-2; liver carboxylesterase 1; microsomal carboxyesterase E1-like; neutral retinyl ester hydrolase; retinyl ester hydrolase

NP_058700.1

EC 3.1.1.1

XP_006255234.2

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017004.1 → NP_058700.1 carboxylesterase 1C precursor

See identical proteins and their annotated locations for NP_058700.1

Status: PROVISIONAL

Source sequence(s)

BC088251

UniProtKB/Swiss-Prot

P10959, Q5I0K0, Q63106, Q64626

Related

ENSRNOP00000024622.9, ENSRNOT00000024622.9

Conserved Domains (1) summary

pfam00135
Location:24 → 532

COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

30099383..30128531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255172.5 → XP_006255234.2 carboxylesterase 1C isoform X1

UniProtKB/Swiss-Prot

P10959, Q5I0K0, Q63106, Q64626

Conserved Domains (1) summary

pfam00135
Location:24 → 534

COesterase; Carboxylesterase family