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    Ppm1l protein phosphatase 1 (formerly 2C)-like [ Mus musculus (house mouse) ]

    Gene ID: 242083, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ppm1lprovided by MGI
    Official Full Name
    protein phosphatase 1 (formerly 2C)-likeprovided by MGI
    Primary source
    MGI:MGI:2139740
    See related
    Ensembl:ENSMUSG00000027784 AllianceGenome:MGI:2139740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2C; Pp2ce; Ppp2ce; mKIAA4175; 3222401G13; PP2Cepsilon; 5930404J21Rik
    Summary
    Enables protein serine/threonine phosphatase activity. Acts upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including ganglia; gut; limb segment; metanephros; and sensory organ. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 7.4), cortex adult (RPKM 6.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppm1l in Genome Data Viewer
    Location:
    3 E1; 3 32.21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69224251..69468131)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69316918..69560798)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:69061014-69061315 Neighboring gene ADP-ribosylation factor-like 14 Neighboring gene predicted gene, 40070 Neighboring gene STARR-positive B cell enhancer ABC_E9551 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07921 Neighboring gene STARR-seq mESC enhancer starr_07922 Neighboring gene ubiquitin-like modifier activating enzyme 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3437 Neighboring gene predicted gene, 52607 Neighboring gene STARR-seq mESC enhancer starr_07923 Neighboring gene STARR-seq mESC enhancer starr_07924 Neighboring gene STARR-seq mESC enhancer starr_07925 Neighboring gene STARR-seq mESC enhancer starr_07926 Neighboring gene UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. Ren S, et al. PLoS One, 2014. PMID 25369058, Free PMC Article
    2. Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites. Shinoda Y, et al. FEBS Lett, 2012 Sep 21. PMID 22796112
    3. Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon. Saito J, et al. Biochem J, 2007 Aug 1. PMID 17456047, Free PMC Article
    4. The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Imanaka-Yoshida K, et al. Differentiation, 2003 Jun. PMID 12823230
    5. A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2. Henmi T, et al. Biochem J, 2009 Sep 14. PMID 19594441

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study provided evidence that PPM1L is involved in the development of the central nervous system.
      Title: Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.
    2. This study provides the first in vivo evidence that PP2Ce is an essential regulator of normal lactation, possibly involving IRE1 signaling and endoplasmic reticulum stress regulation in mammary epithelium.
      Title: IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.
    3. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
      Title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
    4. in the absence of IL-1-induced signal, PP2Cepsilon contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK1.
      Title: Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4175

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1L
    Names
    PP2C-epsilon
    protein phosphatase 1-like
    protein phosphatase 2C epsilon
    NP_848841.2
    XP_006501533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178726.3 → NP_848841.2  protein phosphatase 1L

      See identical proteins and their annotated locations for NP_848841.2

      Status: PROVISIONAL

      Source sequence(s)
      AC111096, AC112685
      Consensus CDS
      CCDS17405.1
      UniProtKB/Swiss-Prot
      Q3UGL2, Q810H0, Q8BHN0, Q8C021, Q8C1D5, Q9Z0T1
      Related
      ENSMUSP00000029355.7, ENSMUST00000029355.9
      Conserved Domains (1) summary
      cd00143
      Location:93 → 351
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      69224251..69468131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501470.4 → XP_006501533.1  protein phosphatase 1L isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:30 → 246
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHN0.1 GenPept UniProtKB/Swiss-Prot:Q8BHN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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