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    Sik2 salt inducible kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 235344, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sik2provided by MGI
    Official Full Name
    salt inducible kinase 2provided by MGI
    Primary source
    MGI:MGI:2445031
    See related
    Ensembl:ENSMUSG00000037112 AllianceGenome:MGI:2445031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snf1lk2; G630080D20Rik
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including protein phosphorylation; regulation of insulin receptor signaling pathway; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within insulin receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and heart. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sik2 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50800944..50920432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50889644..51009132, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury. van Gijsel-Bonnello M, et al. J Biol Chem, 2022 Dec. PMID 36309093, Free PMC Article
    2. SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes. Du J, et al. Obesity (Silver Spring), 2008 Mar. PMID 18239551
    3. Bosutinib Attenuates Inflammation via Inhibiting Salt-Inducible Kinases in Experimental Model of Intracerebral Hemorrhage on Mice. Ma L, et al. Stroke, 2017 Nov. PMID 29018127, Free PMC Article
    4. Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake. Popov S, et al. PLoS One, 2014. PMID 24752134, Free PMC Article
    5. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases. Ozanne J, et al. Biochem J, 2015 Jan 15. PMID 25351958, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
      Title: Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
    2. SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
      Title: SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
    3. Salt inducible kinases 2 and 3 are required for thymic T cell development.
      Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
    4. Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
      Title: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
    5. Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
      Title: Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
    6. Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
      Title: Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
    7. Salt-inducible Kinases Are Critical Determinants of Female Fertility.
      Title: Salt-inducible Kinases Are Critical Determinants of Female Fertility.
    8. Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
      Title: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
    9. Silencing Sik2 further diminished SIRT3 activity and enhanced acetylation of PDHA1 K83 level. Reconstruction of SIRT3 restored PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout (KO) mice.
      Title: Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions.
    10. hippocampal SIK2-CRTC1 pathway is involved in the pathogenesis of depression.
      Title: Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription from RNA polymerase II promoter by glucose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription from RNA polymerase II promoter by glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SIK-2
    SNF1-like kinase 2
    salt induceable kinase 2
    salt-inducible protein kinase 2
    serine/threonine-protein kinase SNF1-like kinase 2
    NP_001391943.1
    NP_001391944.1
    NP_848825.2
    XP_006510330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405014.1 → NP_001391943.1  serine/threonine-protein kinase SIK2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103406
      UniProtKB/TrEMBL
      H3BKG1
      Related
      ENSMUSP00000135376.2, ENSMUST00000176663.8

    2. NM_001405015.1 → NP_001391944.1  serine/threonine-protein kinase SIK2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC103406

    3. NM_178710.4 → NP_848825.2  serine/threonine-protein kinase SIK2 isoform 1

      See identical proteins and their annotated locations for NP_848825.2

      Status: VALIDATED

      Source sequence(s)
      AC103406
      Consensus CDS
      CCDS40627.1
      UniProtKB/Swiss-Prot
      Q8CFH6
      UniProtKB/TrEMBL
      F8VPT7
      Related
      ENSMUSP00000038761.11, ENSMUST00000041375.11
      Conserved Domains (3) summary
      smart00220
      Location:20 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14409
      Location:297 → 341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19 → 271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50800944..50920432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510267.3 → XP_006510330.1  serine/threonine-protein kinase SIK2 isoform X2

      UniProtKB/Swiss-Prot
      Q8CFH6
      Conserved Domains (2) summary
      cd14409
      Location:297 → 341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19 → 271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RNA

    1. XR_379116.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFH6.1 GenPept UniProtKB/Swiss-Prot:Q8CFH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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