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    Scn3b sodium channel, voltage-gated, type III, beta [ Mus musculus (house mouse) ]

    Gene ID: 235281, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Scn3bprovided by MGI
    Official Full Name
    sodium channel, voltage-gated, type III, betaprovided by MGI
    Primary source
    MGI:MGI:1918882
    See related
    Ensembl:ENSMUSG00000049281 AllianceGenome:MGI:1918882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scnb3; 1110001K16Rik; 4833414B02Rik
    Summary
    Enables transmembrane transporter binding activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upstream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 43.1), whole brain E14.5 (RPKM 26.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scn3b in Genome Data Viewer
    Location:
    9 A5.1; 9 21.42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40180512..40202914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40269216..40291618)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene zinc finger protein 202 Neighboring gene STARR-seq mESC enhancer starr_23849 Neighboring gene STARR-seq mESC enhancer starr_23851 Neighboring gene GRAM domain containing 1B Neighboring gene RIKEN cDNA 1700110K17 gene Neighboring gene STARR-seq mESC enhancer starr_23853 Neighboring gene STARR-seq mESC enhancer starr_23854 Neighboring gene STARR-positive B cell enhancer mm9_chr9:40222671-40222972 Neighboring gene predicted gene, 51668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse. Nutini M, et al. Mol Cell Neurosci, 2011 Jun. PMID 21458573
    2. Study of the residues involved in the binding of β1 to β3 subunits in the sodium channel. Liu Q, et al. C R Biol, 2014 Feb. PMID 24581800
    3. Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties. Hakim P, et al. Acta Physiol (Oxf), 2010 Jan. PMID 19796257, Free PMC Article
    4. Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Hakim P, et al. Prog Biophys Mol Biol, 2008 Oct-Nov. PMID 19351516, Free PMC Article
    5. Identification of SCN3B as a novel p53-inducible proapoptotic gene. Adachi K, et al. Oncogene, 2004 Oct 14. PMID 15334053

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis
      Title: Study of the residues involved in the binding of β1 to β3 subunits in the sodium channel.
    2. This study demonistrated that scn3b gene expression in mouse dorsal raphe nucleus
      Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
    3. These data suggest that the SOD1G93A mutation results in increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord..
      Title: Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse.
    4. deficiency in Scn3b results in significant atrial electrophysiological and intracardiac conduction abnormalities
      Title: Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties.
    5. Bipolar electrogram and monophasic action potential recordings from the ventricles of Langendorff-perfused Scn3b(-/-) hearts demonstrated ventricular tachycardias induced by programmed electrical stimulation.
      Title: Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.
    6. SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs.
      Title: Identification of SCN3B as a novel p53-inducible proapoptotic gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sodium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrial cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac muscle cell action potential involved in contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane depolarization during action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane depolarization during cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane depolarization during cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of atrial cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium channel regulatory subunit beta-3
    Names
    brain and heart sodium channel beta 3 subunit
    sodium channel subunit beta-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083917.1 → NP_001077386.1  sodium channel regulatory subunit beta-3 isoform a precursor

      See identical proteins and their annotated locations for NP_001077386.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 2. Variants 2, 3 and 5 encode the same protein (isoform a).
      Source sequence(s)
      BC053919, CB520894
      Consensus CDS
      CCDS23080.1
      UniProtKB/Swiss-Prot
      Q8BHK2, Q91Z99
      UniProtKB/TrEMBL
      Q0P666, Q69ZQ3
      Related
      ENSMUSP00000051627.6, ENSMUST00000049941.12
      Conserved Domains (1) summary
      pfam07686
      Location:28 → 122
      V-set; Immunoglobulin V-set domain

    2. NM_001286614.1 → NP_001273543.1  sodium channel regulatory subunit beta-3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' splice site, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform b, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      BC058083, BC058636, CB520894
      Consensus CDS
      CCDS72214.1
      UniProtKB/TrEMBL
      H3BJR6
      Related
      ENSMUSP00000135096.2, ENSMUST00000176185.8
      Conserved Domains (2) summary
      pfam07686
      Location:2 → 82
      V-set; Immunoglobulin V-set domain
      cd00096
      Location:33 → 38
      Ig; Ig strand C' [structural motif]

    3. NM_001359700.1 → NP_001346629.1  sodium channel regulatory subunit beta-3 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR, compared to variant 2. Variants 2, 3 and 5 encode the same protein (isoform a).
      Source sequence(s)
      AC135353, BC058636
      Consensus CDS
      CCDS23080.1
      UniProtKB/Swiss-Prot
      Q8BHK2, Q91Z99
      UniProtKB/TrEMBL
      Q0P666, Q69ZQ3
      Conserved Domains (1) summary
      pfam07686
      Location:28 → 122
      V-set; Immunoglobulin V-set domain

    4. NM_178227.4 → NP_839941.1  sodium channel regulatory subunit beta-3 isoform a precursor

      See identical proteins and their annotated locations for NP_839941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 2, 3 and 5 encode the same protein (isoform a).
      Source sequence(s)
      AK049747, BC053919, CB520894
      Consensus CDS
      CCDS23080.1
      UniProtKB/Swiss-Prot
      Q8BHK2, Q91Z99
      UniProtKB/TrEMBL
      Q0P666, Q69ZQ3
      Related
      ENSMUSP00000132933.3, ENSMUST00000171835.9
      Conserved Domains (1) summary
      pfam07686
      Location:28 → 122
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      40180512..40202914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153522.2: Suppressed sequence

      Description
      NM_153522.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHK2.1 GenPept UniProtKB/Swiss-Prot:Q8BHK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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