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    FOLR3 folate receptor gamma [ Homo sapiens (human) ]

    Gene ID: 2352, updated on 17-Sep-2024

    Summary

    Official Symbol
    FOLR3provided by HGNC
    Official Full Name
    folate receptor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3795
    See related
    Ensembl:ENSG00000110203 MIM:602469; AllianceGenome:HGNC:3795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FR-G; FRgamma; FR-gamma; gamma-hFR
    Summary
    This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Biased expression in bone marrow (RPKM 27.0), appendix (RPKM 4.9) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FOLR3 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72135725..72139892)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72062611..72066776)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71846771..71850936)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823011-71823548 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71823549-71824086 Neighboring gene anaphase promoting complex subunit 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:71824087-71824624 Neighboring gene transmembrane O-methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71849877-71850378 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene MPRA-validated peak1339 silencer Neighboring gene MPRA-validated peak1340 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71875770-71876579 Neighboring gene folate receptor 1 pseudogene 1 Neighboring gene folate receptor 3 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in folic acid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extrinsic component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    folate receptor gamma
    Names
    folate receptor 3 (gamma)
    NP_000795.2
    NP_001399199.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032935.1 RefSeqGene

      Range
      5001..9168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000804.4NP_000795.2  folate receptor gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_000795.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform 1.
      Source sequence(s)
      BC030285, CD368314, U08471
      Consensus CDS
      CCDS73344.1
      UniProtKB/Swiss-Prot
      A0A087WXH3, J3KQ90, P41439, Q05C14
      Related
      ENSP00000481114.1, ENST00000611028.3
      Conserved Domains (1) summary
      pfam03024
      Location:36211
      Folate_rec; Folate receptor family
    2. NM_001412270.1NP_001399199.1  folate receptor gamma isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, coding) represents the allele encoded by the T2T-CHM13v2.0 genome assembly and encodes isoform 2.
      Source sequence(s)
      CP068267

    RNA

    1. NR_178088.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant 2 but represents the allele present on the GRCh38 reference genome. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000812, KF459676
      Related
      ENST00000612844.4
    2. NR_178089.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CP068267

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72135725..72139892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      72062611..72066776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)