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    Il17c interleukin 17C [ Mus musculus (house mouse) ]

    Gene ID: 234836, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Il17cprovided by MGI
    Official Full Name
    interleukin 17Cprovided by MGI
    Primary source
    MGI:MGI:2446486
    See related
    Ensembl:ENSMUSG00000046108 AllianceGenome:MGI:2446486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-17C
    Summary
    Enables cytokine activity. Acts upstream of or within neutrophil differentiation and positive regulation of cytokine production involved in inflammatory response. Located in extracellular space. Orthologous to human IL17C (interleukin 17C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 1.3), thymus adult (RPKM 0.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il17c in Genome Data Viewer
    Location:
    8 E1; 8 71.03 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123147912..123150820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122422020..122423639)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6697 Neighboring gene thyrotropin releasing hormone receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E6698 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E9324 Neighboring gene STARR-positive B cell enhancer ABC_E8269 Neighboring gene STARR-positive B cell enhancer ABC_E1776 Neighboring gene cytochrome b-245, alpha polypeptide Neighboring gene predicted gene, 53466 Neighboring gene mevalonate (diphospho) decarboxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-17C neutralization protects the kidney against acute injury and chronic injury.
      Title: IL-17C neutralization protects the kidney against acute injury and chronic injury.
    2. IL-17C has a pathogenic role in kidney ischemia/reperfusion injury.
      Title: IL-17C has a pathogenic role in kidney ischemia/reperfusion injury.
    3. IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
      Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
    4. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
      Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
    5. Authors found that IL-17c can effectively activate OM cells through the release of ATP. In the longer term, intranasal chronic instillations of IL-17c increased the cellular dynamics of the epithelium and promoted immune cells infiltrations.
      Title: IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence.
    6. Our results indicate that Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/IL-17C signaling.
      Title: Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/interleukin-17C signaling.
    7. These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of S. pneumoniae lung infection.
      Title: Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia.
    8. results are the first demonstrating the protective role of IL-17C in Acute graft-vs.-host disease (aGVHD) by promoting intestinal barrier functions and Treg differentiation in a MHC fully mismatched murine aGVHD model. IL-17C may serve as a novel biomarker and potential therapeutic target for aGVHD.
      Title: IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation.
    9. In mouse models of crescentic GN (nephrotoxic nephritis) and pristane-induced lupus nephritis, deficiency in IL-17C significantly ameliorated the course of GN in terms of renal tissue injury and kidney function. IL-17C is produced by renal tissue-resident cells, but not by lymphocytes. IL-17C promotes TH17 cell responses and immune-mediated kidney disease via IL-17RE expressed on CD4(+) TH17 cells.
      Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
    10. Study utilizing human skin samples, cultured primary human and mouse keratinocytes, and mouse disease models indicates that IL-17C is a central mediator of skin inflammation beyond psoriasis and is relevant in particular in atopic dermatitis.
      Title: Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC175740

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neutrophil differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-17C
    Names
    cytokine CX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145834.5 → NP_665833.4  interleukin-17C

      Status: VALIDATED

      Source sequence(s)
      AL591003
      Consensus CDS
      CCDS90473.1
      UniProtKB/Swiss-Prot
      A6H6F0, Q8K4C5
      UniProtKB/TrEMBL
      A0A0R4J0P4
      Related
      ENSMUSP00000056008.4, ENSMUST00000050963.4
      Conserved Domains (1) summary
      pfam06083
      Location:88 → 176
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123147912..123150820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153977.1 → XP_036009870.1  interleukin-17C isoform X1

      UniProtKB/Swiss-Prot
      A6H6F0, Q8K4C5
      Conserved Domains (1) summary
      pfam06083
      Location:108 → 196
      IL17; Interleukin-17
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4C5.1 GenPept UniProtKB/Swiss-Prot:Q8K4C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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