Acsm4 acyl-CoA synthetase medium-chain family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acsm4provided by MGI
Official Full Name: acyl-CoA synthetase medium-chain family member 4provided by MGI
Primary source: MGI:MGI:2681844
See related: Ensembl:ENSMUSG00000047026 AllianceGenome:MGI:2681844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OMACS; O-MACS
Summary: Predicted to enable decanoate-CoA ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in nervous system; nose; and olfactory epithelium. Orthologous to human ACSM4 (acyl-CoA synthetase medium chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 64.1 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119289249..119313789)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119690026..119714566)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables decanoate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid ligase activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA synthase activity	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A synthetase ACSM4, mitochondrial

Names: olfactory specific medium-chain acyl CoA synthetase

NP_848501.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178414.3 → NP_848501.1 acyl-coenzyme A synthetase ACSM4, mitochondrial precursor

See identical proteins and their annotated locations for NP_848501.1

Status: VALIDATED

Source sequence(s)

AK132127, BY588281

Consensus CDS

CCDS21784.1

UniProtKB/Swiss-Prot

Q80W40

Related

ENSMUSP00000045160.9, ENSMUST00000047045.10

Conserved Domains (2) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

COG0365
Location:49 → 576

Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]