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    Hcrtr1 hypocretin (orexin) receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 230777, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hcrtr1provided by MGI
    Official Full Name
    hypocretin (orexin) receptor 1provided by MGI
    Primary source
    MGI:MGI:2385650
    See related
    Ensembl:ENSMUSG00000028778 AllianceGenome:MGI:2385650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox1r; ox1-R; ox-1-R
    Summary
    Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 6.3), stomach adult (RPKM 2.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hcrtr1 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130024010..130033389, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130130217..130139594, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene collagen, type XVI, alpha 1 Neighboring gene predicted gene, 46871 Neighboring gene STARR-positive B cell enhancer ABC_E1656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129785190-129785373 Neighboring gene predicted gene, 40258 Neighboring gene penta-EF hand domain containing 1 Neighboring gene predicted gene, 40259 Neighboring gene tubulointerstitial nephritis antigen-like 1 Neighboring gene predicted gene, 52490

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward. Flores Á, et al. Biol Psychiatry, 2014 Mar 15. PMID 23896204
    2. Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. Hollander JA, et al. Front Behav Neurosci, 2012. PMID 22837742, Free PMC Article
    3. Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence. Carvajal F, et al. Behav Brain Res, 2015. PMID 25827928
    4. Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior. Yaeger JDW, et al. Biol Psychiatry, 2022 May 1. PMID 35279280, Free PMC Article
    5. Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice. Lei K, et al. Neuropharmacology, 2016 Nov. PMID 27523303, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
      Title: Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model.
    2. alpha-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
      Title: α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
    3. Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model.
      Title: Antagonization of OX(1) Receptor Potentiates CB(2) Receptor Function in Microglia from APP(Sw/Ind) Mice Model.
    4. The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
      Title: The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
    5. Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.
      Title: Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.
    6. Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510.
      Title: Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510.
    7. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
      Title: Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
    8. Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice.
      Title: Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice.
    9. Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking.
      Title: Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking.
    10. Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.
      Title: Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orexin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables orexin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    orexin/Hypocretin receptor type 1
    Names
    hypocretin receptor type 1
    orexin receptor type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163027.2 → NP_001156499.1  orexin/Hypocretin receptor type 1 isoform 1

      See identical proteins and their annotated locations for NP_001156499.1

      Status: VALIDATED

      Source sequence(s)
      AL606925
      Consensus CDS
      CCDS18707.1
      UniProtKB/Swiss-Prot
      P58307, Q0VDP5, Q3USS9, Q6VNS3, Q80T45
      Related
      ENSMUSP00000113198.3, ENSMUST00000120154.9
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001305392.2 → NP_001292321.1  orexin/Hypocretin receptor type 1 isoform 2

      See identical proteins and their annotated locations for NP_001292321.1

      Status: VALIDATED

      Source sequence(s)
      AL606925
      UniProtKB/TrEMBL
      Q0VDP6
      Conserved Domains (2) summary
      cd14964
      Location:37 → 66
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:1 → 194
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001357258.2 → NP_001344187.1  orexin/Hypocretin receptor type 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606925
      UniProtKB/TrEMBL
      Q0VDP6
      Conserved Domains (2) summary
      cd14964
      Location:37 → 66
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:1 → 194
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_001426068.1 → NP_001412997.1  orexin/Hypocretin receptor type 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606925
      UniProtKB/TrEMBL
      Q0VDP6

    5. NM_001426069.1 → NP_001412998.1  orexin/Hypocretin receptor type 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606925
      UniProtKB/Swiss-Prot
      P58307, Q0VDP5, Q3USS9, Q6VNS3, Q80T45
      Related
      ENSMUSP00000127290.3, ENSMUST00000164887.3

    6. NM_198959.3 → NP_945197.2  orexin/Hypocretin receptor type 1 isoform 1

      See identical proteins and their annotated locations for NP_945197.2

      Status: VALIDATED

      Source sequence(s)
      AL606925
      Consensus CDS
      CCDS18707.1
      UniProtKB/Swiss-Prot
      P58307, Q0VDP5, Q3USS9, Q6VNS3, Q80T45
      Related
      ENSMUSP00000030562.7, ENSMUST00000030562.13
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130024010..130033389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164062.1 → XP_036019955.1  orexin/Hypocretin receptor type 1 isoform X2

      UniProtKB/TrEMBL
      Q0VDP6
      Conserved Domains (2) summary
      cd14964
      Location:37 → 66
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:1 → 194
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_036164060.1 → XP_036019953.1  orexin/Hypocretin receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      P58307, Q0VDP5, Q3USS9, Q6VNS3, Q80T45
      Related
      ENSMUSP00000112630.2, ENSMUST00000119423.8
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_017320157.3 → XP_017175646.1  orexin/Hypocretin receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      P58307, Q0VDP5, Q3USS9, Q6VNS3, Q80T45
      Conserved Domains (1) summary
      cd15208
      Location:47 → 369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58307.3 GenPept UniProtKB/Swiss-Prot:P58307

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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