U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Lzts2 leucine zipper, putative tumor suppressor 2 [ Mus musculus (house mouse) ]

    Gene ID: 226154, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lzts2provided by MGI
    Official Full Name
    leucine zipper, putative tumor suppressor 2provided by MGI
    Primary source
    MGI:MGI:2385095
    See related
    Ensembl:ENSMUSG00000035342 AllianceGenome:MGI:2385095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAPSER1; mKIAA1813
    Summary
    Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast proliferation; and tube morphogenesis. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; adrenal gland; forelimb bud; future brain; and genitourinary system. Used to study urinary system disease. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 94.4), ovary adult (RPKM 63.9) and 24 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lzts2 in Genome Data Viewer
    Location:
    19 C3; 19 38.2 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45003615..45015554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45015176..45027115)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G Neighboring gene STARR-positive B cell enhancer ABC_E9998 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45131818-45132020 Neighboring gene STARR-positive B cell enhancer ABC_E9175 Neighboring gene predicted gene, 35782 Neighboring gene Kazal-type serine peptidase inhibitor domain 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis. Yu EJ, et al. PLoS One, 2017. PMID 28323888, Free PMC Article
    2. Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development. Johnson DT, et al. J Biol Chem, 2013 Feb 8. PMID 23275340, Free PMC Article
    3. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. Peng Y, et al. J Biol Chem, 2011 Nov 18. PMID 21949185, Free PMC Article
    4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis.
      Title: LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis.
    2. deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development.
      Title: Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
    3. a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis.
      Title: The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC7094

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within primary ureteric bud growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ureter morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine zipper putative tumor suppressor 2
    Names
    protein LAPSER1
    putative tumor suppressor LAPSER1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130525.1 → NP_001123997.1  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_001123997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AA208269, AK129446, BX511791, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Related
      ENSMUSP00000137571.2, ENSMUST00000179108.9
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    2. NM_001130526.1 → NP_001123998.1  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_001123998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AA208269, AK129446, BY726859, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Related
      ENSMUSP00000136405.2, ENSMUST00000178087.3
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    3. NM_145503.2 → NP_663478.2  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_663478.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AA208269, AK129446, BY202542, CK021048
      Consensus CDS
      CCDS29855.1
      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Related
      ENSMUSP00000045478.7, ENSMUST00000039016.14
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45003615..45015554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527004.4 → XP_006527067.1  leucine zipper putative tumor suppressor 2 isoform X1

      See identical proteins and their annotated locations for XP_006527067.1

      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    2. XM_030250898.2 → XP_030106758.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    3. XM_030250899.2 → XP_030106759.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      E9QKK6, Q569X6, Q91YU6
      Conserved Domains (2) summary
      pfam06818
      Location:441 → 637
      Fez1
      pfam13851
      Location:404 → 476
      GAS; Growth-arrest specific micro-tubule binding

    4. XM_006527005.5 → XP_006527068.1  leucine zipper putative tumor suppressor 2 isoform X3

      See identical proteins and their annotated locations for XP_006527068.1

      Conserved Domains (2) summary
      pfam06818
      Location:220 → 416
      Fez1
      pfam13851
      Location:183 → 255
      GAS; Growth-arrest specific micro-tubule binding

    5. XM_030250900.1 → XP_030106760.1  leucine zipper putative tumor suppressor 2 isoform X2

      Conserved Domains (2) summary
      pfam06818
      Location:304 → 500
      Fez1
      pfam13851
      Location:267 → 339
      GAS; Growth-arrest specific micro-tubule binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YU6.3 GenPept UniProtKB/Swiss-Prot:Q91YU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools