Tnr tenascin R [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnrprovided by MGI
Official Full Name: tenascin Rprovided by MGI
Primary source: MGI:MGI:99516
See related: Ensembl:ENSMUSG00000015829 AllianceGenome:MGI:99516
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TN-R; janusin; restrictin; J1-tenascin
Summary: Predicted to enable integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and regulation of cell migration. Acts upstream of or within several processes, including locomotory exploration behavior; modulation of chemical synaptic transmission; and negative regulation of axon extension involved in regeneration. Located in cell surface; membrane raft; and perineuronal net. Part of tenascin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including aorta tunica media; brain; heart; urinary system; and ventral grey horn. Orthologous to human TNR (tenascin R). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 6.9), cortex adult (RPKM 6.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H1; 1 69.03 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (159351170..159759299)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (159523729..159931729)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
Title: The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Title: Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack tenascin-C, the informational content stored by synaptic plasticity is not the same.
Title: Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.
Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan.
Title: Tenascin-R promotes assembly of the extracellular matrix of perineuronal nets via clustering of aggrecan.
Aggrecan, link protein and TN-R were identified to be essential for the neuroprotective properties of the perineuronal net.
Title: Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress.
These findings indicate the importance of TNR in the regulation of hippocampal neurogenesis and suggest that TNR acts through distinct direct and indirect mechanisms during development and in the adult.
Title: The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.
TNR is expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic GLAST expression.
Title: Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes.
Our results indicate that TNR modulates adult but not developmental neurogenesis in the olfactory bulb
Title: The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb.
This study provided evidence that the tenascin-R modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Title: Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.
Ablation of TNR modifies the extracellular matrix and leads to reorganization of the dentate gyrus with enhanced GABAergic innervation and altered plasticity, promoting working memory and reversal learning.
Title: Improved reversal learning and working memory and enhanced reactivity to novelty in mice with enhanced GABAergic innervation in the dentate gyrus.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit219 (e-PCR), detects polymorphism
- UniSTS:128561

C86103 (e-PCR)
- UniSTS:185455

29.MMHAP6FRB11.seq (e-PCR)
- UniSTS:123871

D1Mit159 (e-PCR), detects polymorphism
- UniSTS:128496

D1Mit159.1 (e-PCR), detects polymorphism
- UniSTS:128497

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix of synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in perineuronal net	IDA Inferred from Direct Assay more info	PubMed
is_active_in perisynaptic extracellular matrix	ISO Inferred from Sequence Orthology more info
part_of tenascin complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: tenascin-R

Names: neural recognition molecule J1-160/180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022312.3 → NP_071707.2 tenascin-R precursor

See identical proteins and their annotated locations for NP_071707.2

Status: VALIDATED

Source sequence(s)

AK039390, AK078229, BC138043

Consensus CDS

CCDS15403.1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Related

ENSMUSP00000141553.2, ENSMUST00000192069.6

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

159351170..159759299

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496745.5 → XP_006496808.1 tenascin-R isoform X2

Conserved Domains (3) summary

smart00186
Location:975 → 1184

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:883 → 968

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:528 → 607

fn3; Fibronectin type III domain
XM_036163559.1 → XP_036019452.1 tenascin-R isoform X1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_036163560.1 → XP_036019453.1 tenascin-R isoform X1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_036163561.1 → XP_036019454.1 tenascin-R isoform X2

Conserved Domains (3) summary

smart00186
Location:975 → 1184

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:883 → 968

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:528 → 607

fn3; Fibronectin type III domain
XM_030252977.2 → XP_030108837.1 tenascin-R isoform X3

Conserved Domains (3) summary

smart00186
Location:801 → 1010

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:709 → 794

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:354 → 430

fn3; Fibronectin type III domain
XM_006496742.5 → XP_006496805.1 tenascin-R isoform X1

See identical proteins and their annotated locations for XP_006496805.1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_006496746.5 → XP_006496809.1 tenascin-R isoform X3

Conserved Domains (3) summary

smart00186
Location:801 → 1010

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:709 → 794

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:354 → 430

fn3; Fibronectin type III domain
XM_030252974.2 → XP_030108834.1 tenascin-R isoform X1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_006496743.4 → XP_006496806.1 tenascin-R isoform X1

See identical proteins and their annotated locations for XP_006496806.1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_036163563.1 → XP_036019456.1 tenascin-R isoform X2

Conserved Domains (3) summary

smart00186
Location:975 → 1184

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:883 → 968

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:528 → 607

fn3; Fibronectin type III domain
XM_030252975.2 → XP_030108835.1 tenascin-R isoform X1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA
XM_006496744.5 → XP_006496807.1 tenascin-R isoform X1

See identical proteins and their annotated locations for XP_006496807.1

UniProtKB/Swiss-Prot

A2RT70, O88717, Q8BYI9

Conserved Domains (5) summary

smart00186
Location:1134 → 1343

FBG; Fibrinogen-related domains (FReDs)

cd00063
Location:1042 → 1127

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:203 → 231

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:687 → 766

fn3; Fibronectin type III domain

NF033759
Location:190 → 328

exchanger_TraA; outer membrane exchange protein TraA