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    Ice1 interactor of little elongation complex ELL subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 218333, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ice1provided by MGI
    Official Full Name
    interactor of little elongation complex ELL subunit 1provided by MGI
    Primary source
    MGI:MGI:2385865
    See related
    Ensembl:ENSMUSG00000034525 AllianceGenome:MGI:2385865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0947
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Predicted to be located in Cajal body; euchromatin; and histone locus body. Predicted to be part of transcription elongation factor complex. Orthologous to human ICE1 (interactor of little elongation complex ELL subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 34.3), whole brain E14.5 (RPKM 24.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ice1 in Genome Data Viewer
    Location:
    13 C1; 13 35.97 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (70736808..70785958, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (70588688..70637839, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36216 Neighboring gene STARR-seq mESC enhancer starr_34952 Neighboring gene STARR-seq mESC enhancer starr_34953 Neighboring gene RIKEN cDNA 1700100L14 gene Neighboring gene predicted gene, 36267 Neighboring gene STARR-seq mESC enhancer starr_34954 Neighboring gene STARR-seq mESC enhancer starr_34956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:70776299-70776482 Neighboring gene predicted gene, 40996 Neighboring gene RIKEN cDNA D030007L05 gene Neighboring gene predicted gene, 36377 Neighboring gene predicted gene, 36474 Neighboring gene predicted gene, 36426

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Shen X, et al. Cell, 2009 Dec 24. PMID 20064376, Free PMC Article
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27742

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in histone locus body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in histone locus body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    little elongation complex subunit 1
    Names
    interactor of little elongator complex ELL subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144837.3 → NP_659086.2  little elongation complex subunit 1

      See identical proteins and their annotated locations for NP_659086.2

      Status: VALIDATED

      Source sequence(s)
      AC113508
      Consensus CDS
      CCDS49309.1
      UniProtKB/Swiss-Prot
      E9Q286, Q6ZQ20
      Related
      ENSMUSP00000036482.6, ENSMUST00000043493.7
      Conserved Domains (2) summary
      pfam13870
      Location:53 → 185
      DUF4201; Domain of unknown function (DUF4201)
      cl09810
      Location:26 → 180
      DUF2031; Protein of unknown function (DUF2031)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      70736808..70785958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247229.2 → XP_030103089.1  little elongation complex subunit 1 isoform X1

      Conserved Domains (1) summary
      cl38910
      Location:1729 → 1754
      ATP-synt_F1_V1_A1_AB_FliI_C; ATP synthase, alpha/beta subunits of F1/V1/A1 complex, flagellum-specific ATPase FliI, C-terminal domain

    RNA

    1. XR_382437.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q286.1 GenPept UniProtKB/Swiss-Prot:E9Q286

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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