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    Tfpi2 tissue factor pathway inhibitor 2 [ Mus musculus (house mouse) ]

    Gene ID: 21789, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Tfpi2provided by MGI
    Official Full Name
    tissue factor pathway inhibitor 2provided by MGI
    Primary source
    MGI:MGI:108543
    See related
    Ensembl:ENSMUSG00000029664 AllianceGenome:MGI:108543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP5/TFPI-2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation; cellular response to fluid shear stress; and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; liver; lung; small intestine; and spleen. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 13.4), placenta adult (RPKM 12.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfpi2 in Genome Data Viewer
    Location:
    6 A1; 6 1.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3962589..3988977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3962589..3988978, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcitonin receptor Neighboring gene predicted gene, 33576 Neighboring gene STARR-seq mESC enhancer starr_15003 Neighboring gene STARR-seq mESC enhancer starr_15005 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_15006 Neighboring gene guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 Neighboring gene guanine nucleotide binding protein (G protein), gamma 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.
      Title: Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.
    2. TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
      Title: TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
    3. TFPI-2 Protects Against Gram-Negative Bacterial Infection.
      Title: TFPI-2 Protects Against Gram-Negative Bacterial Infection.
    4. Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein
      Title: S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin.
    5. A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis.
      Title: Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
    6. Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases.
      Title: Over-expression of TFPI-2 promotes atherosclerotic plaque stability by inhibiting MMPs in apoE-/- mice.
    7. Dynamic changes of Tfpi2 associated with Il-1beta and Tnf-alpha in the development of acute lung injury are reported.
      Title: Dynamic changes of tissue factor pathway inhibitor type 2 associated with IL-1beta and TNF-alpha in the development of murine acute lung injury.
    8. Deficiency for the histone methyltransferase EHMT2 or for the Polycomb group protein EED, leads to biallelic expression of Tfpi2 in the extra-embryonic lineages, whereas the other genes in the cluster maintain correct imprinting.
      Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
    9. Bovine TFPI2 was compared to mouse TFPI2.
      Title: Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.
    10. Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes.
      Title: Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tissue factor pathway inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381907.1 → NP_001368836.1  tissue factor pathway inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022235
      Conserved Domains (2) summary
      cd00109
      Location:30 → 83
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:151 → 203
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. NM_001381908.1 → NP_001368837.1  tissue factor pathway inhibitor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC022235
      Conserved Domains (2) summary
      cd00109
      Location:70 → 123
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:191 → 243
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    3. NM_009364.4 → NP_033390.1  tissue factor pathway inhibitor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AK132268, BU755117
      Consensus CDS
      CCDS19892.1
      UniProtKB/Swiss-Prot
      O35536
      UniProtKB/TrEMBL
      Q3V1S9
      Related
      ENSMUSP00000031674.8, ENSMUST00000031674.11
      Conserved Domains (2) summary
      cd00109
      Location:34 → 87
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:155 → 206
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RNA

    1. NR_138566.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' terminal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq criteria.
      Source sequence(s)
      AC022235

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      3962589..3988977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241056.3 → XP_011239358.1  tissue factor pathway inhibitor 2 isoform X2

      Conserved Domains (1) summary
      pfam00014
      Location:90 → 141
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. XM_011241055.4 → XP_011239357.1  tissue factor pathway inhibitor 2 isoform X1

      See identical proteins and their annotated locations for XP_011239357.1

      UniProtKB/Swiss-Prot
      O35536
      UniProtKB/TrEMBL
      Q3V1S9
      Conserved Domains (2) summary
      cd00109
      Location:34 → 87
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:155 → 206
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35536.1 GenPept UniProtKB/Swiss-Prot:O35536

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