U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    FAAH fatty acid amide hydrolase [ Homo sapiens (human) ]

    Gene ID: 2166, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FAAHprovided by HGNC
    Official Full Name
    fatty acid amide hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:3553
    See related
    Ensembl:ENSG00000117480 MIM:602935; AllianceGenome:HGNC:3553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSAB; FAAH1; FAAH-1
    Summary
    This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FAAH in Genome Data Viewer
    Location:
    1p33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46394317..46413845)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46271530..46291059)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46859989..46879517)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46768959-46769542 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46769543-46770124 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46794429-46795157 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:46795158-46795887 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46795888-46796616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46797347-46798076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 845 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46804880-46805679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1000 Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene MPRA-validated peak205 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:46837735-46837899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46859877-46860390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46898417-46899137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1003 Neighboring gene fatty acid amide hydrolase pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46913491-46914002 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46914003-46914516 Neighboring gene long intergenic non-protein coding RNA 1398

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway. Ravi J, et al. Oncotarget, 2014 May 15. PMID 24811863, Free PMC Article
    2. Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. de Luis D, et al. J Diabetes Complications, 2013 May-Jun. PMID 23333123
    3. Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity. Gebeh AK, et al. J Clin Endocrinol Metab, 2013 Mar. PMID 23372171
    4. Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population. Sim MS, et al. Pharmacogenomics, 2013 Apr. PMID 23556448
    5. Lack of association between C385A functional polymorphism of the fatty acid amide hydrolase gene and polycystic ovary syndrome. Grolmusz VK, et al. Exp Clin Endocrinol Diabetes, 2013 Jun. PMID 23616186

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
      Title: Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
    2. FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.
      Title: FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.
    3. Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.
      Title: Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.
    4. Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [[11]C]CURB in Heavy-Drinking Youth.
      Title: Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [(11)C]CURB in Heavy-Drinking Youth.
    5. Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.
      Title: Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.
    6. Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.
      Title: Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.
    7. The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.
      Title: The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.
    8. Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.
      Title: Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.
    9. Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.
      Title: Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.
    10. Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.
      Title: Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.
    Submit: New GeneRIF Correction See all GeneRIFs (146)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Polysubstance abuse, susceptibility to
    MedGen: C1847831 OMIM: 606581 GeneReviews: Not available
    		Compare labs

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC102823, MGC138146

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid amide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid amide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid amide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid amide hydrolase activity TAS
    Traceable Author Statement
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoacylglycerol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    fatty-acid amide hydrolase 1
    Names
    anandamide amidohydrolase 1
    fatty acid ester hydrolase
    oleamide hydrolase 1
    NP_001432.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012195.2 RefSeqGene

      Range
      5002..24530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001441.3 → NP_001432.2  fatty-acid amide hydrolase 1

      See identical proteins and their annotated locations for NP_001432.2

      Status: REVIEWED

      Source sequence(s)
      AL122001
      Consensus CDS
      CCDS535.1
      UniProtKB/Swiss-Prot
      D3DQ19, O00519, Q52M86, Q5TDF8
      Related
      ENSP00000243167.8, ENST00000243167.9
      Conserved Domains (1) summary
      pfam01425
      Location:95 → 562
      Amidase; Amidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46394317..46413845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46271530..46291059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00519.2 GenPept UniProtKB/Swiss-Prot:O00519

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous