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    Tcp11 t-complex protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 21463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tcp11provided by MGI
    Official Full Name
    t-complex protein 11provided by MGI
    Primary source
    MGI:MGI:98544
    See related
    Ensembl:ENSMUSG00000062859 AllianceGenome:MGI:98544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcp-11; D17Ken1
    Summary
    Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; protein kinase A signaling; and regulation of sperm capacitation. Located in acrosomal vesicle and sperm midpiece. Is expressed in testis. Orthologous to human TCP11 (t-complex 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 841.9) See more
    Orthologs
    human all
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    Genomic context

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    See Tcp11 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28285725..28299583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28066747..28080726, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and SAM domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3 Neighboring gene zinc finger protein 523

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse t-complex protein 11 is important for progressive motility in sperm†. Castaneda JM, et al. Biol Reprod, 2020 Apr 15. PMID 31837139, Free PMC Article
    2. The mouse t-complex gene, Tcp-11, is under translational control. Hosseini R, et al. Mech Dev, 1994 Jul. PMID 7947323
    3. The modulation of sperm function by fertilization promoting peptide. Fraser LR. Hum Reprod, 1998 Dec. PMID 10091053
    4. Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex. Mazarakis ND, et al. Development, 1991 Feb. PMID 1893875
    5. FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway. Adeoya-Osiguwa SA, et al. Mol Reprod Dev, 1998 Dec. PMID 9820206

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse t-complex protein 11 is important for progressive motility in spermdagger.
      Title: Mouse t-complex protein 11 is important for progressive motility in sperm†.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC107229

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-complex protein 11
    Names
    testis-specific protein PBS13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085555.2 → NP_001079024.1  T-complex protein 11 isoform 2

      See identical proteins and their annotated locations for NP_001079024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC132460
      Consensus CDS
      CCDS50045.1
      UniProtKB/TrEMBL
      Q01756, Q5FWA2
      Related
      ENSMUSP00000046002.9, ENSMUST00000043925.16
      Conserved Domains (1) summary
      pfam05794
      Location:67 → 472
      Tcp11; T-complex protein 11

    2. NM_001357681.2 → NP_001344610.1  T-complex protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132460
      Consensus CDS
      CCDS50045.1
      UniProtKB/TrEMBL
      Q01756, Q5FWA2
      Related
      ENSMUSP00000110485.2, ENSMUST00000114836.9
      Conserved Domains (1) summary
      pfam05794
      Location:67 → 472
      Tcp11; T-complex protein 11

    3. NM_001374620.1 → NP_001361549.1  T-complex protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      A0A3B2W7H0, Q01756
      Related
      ENSMUSP00000156512.2, ENSMUST00000233898.2
      Conserved Domains (1) summary
      pfam05794
      Location:33 → 438
      Tcp11; T-complex protein 11

    4. NM_001374621.1 → NP_001361550.1  T-complex protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      A0A3B2WD68, Q01756
      Related
      ENSMUSP00000156874.2, ENSMUST00000232798.2
      Conserved Domains (1) summary
      pfam05794
      Location:26 → 431
      Tcp11; T-complex protein 11

    5. NM_001399994.1 → NP_001386923.1  T-complex protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      B2KF24, B2KF25

    6. NM_001399995.1 → NP_001386924.1  T-complex protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      B2KF24, B2KF25

    7. NM_001399996.1 → NP_001386925.1  T-complex protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      Q5FWA2

    8. NM_001399998.1 → NP_001386927.1  T-complex protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      Q5FWA2

    9. NM_001399999.1 → NP_001386928.1  T-complex protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132460
      UniProtKB/TrEMBL
      A0A3B2WD68
      Related
      ENSMUST00000233961.2

    10. NM_001400000.1 → NP_001386929.1  T-complex protein 11 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132460

    11. NM_013687.4 → NP_038715.2  T-complex protein 11 isoform 1

      See identical proteins and their annotated locations for NP_038715.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132460
      Consensus CDS
      CCDS37526.1
      UniProtKB/Swiss-Prot
      Q01755
      UniProtKB/TrEMBL
      B2KF24, B2KF25
      Related
      ENSMUSP00000038590.6, ENSMUST00000042692.13
      Conserved Domains (1) summary
      pfam05794
      Location:146 → 548
      Tcp11; T-complex protein 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28285725..28299583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01755.1 GenPept UniProtKB/Swiss-Prot:Q01755

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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