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    Tent5d terminal nucleotidyltransferase 5D [ Mus musculus (house mouse) ]

    Gene ID: 213449, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tent5dprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 5Dprovided by MGI
    Primary source
    MGI:MGI:2685223
    See related
    Ensembl:ENSMUSG00000073007 AllianceGenome:MGI:2685223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm377; Fam46d
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization. Orthologous to human TENT5D (terminal nucleotidyltransferase 5D). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis adult (RPKM 2.0) See more
    Orthologs
    human all
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    Genomic context

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    See Tent5d in Genome Data Viewer
    Location:
    X D; X 47.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106836196..106916517)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107792590..107872911)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-seq mESC enhancer starr_47746 Neighboring gene STARR-seq mESC enhancer starr_47747 Neighboring gene T-box 22 Neighboring gene STARR-seq mESC enhancer starr_47748 Neighboring gene charged multivesicular body protein 1B2 Neighboring gene STARR-seq mESC enhancer starr_47749 Neighboring gene STARR-seq mESC enhancer starr_47750 Neighboring gene STARR-seq mESC enhancer starr_47751 Neighboring gene WAVE homology in membrane protrusions Neighboring gene STARR-seq mESC enhancer starr_47752 Neighboring gene MYST histone acetyltransferase (monocytic leukemia) 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of X-linked TENT5D causes male infertility by disrupting the mRNA stability during spermatogenesis. Cong J, et al. Cell Discov, 2022 Mar 8. PMID 35256600, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    terminal nucleotidyltransferase 5D
    Names
    family with sequence similarity 46, member D
    NP_001156576.1
    NP_001257937.1
    XP_006527999.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163104.2 → NP_001156576.1  terminal nucleotidyltransferase 5D

      See identical proteins and their annotated locations for NP_001156576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK133246, AL669851, BB865956
      Consensus CDS
      CCDS53172.1
      UniProtKB/TrEMBL
      B1ATX6
      Related
      ENSMUSP00000129483.2, ENSMUST00000167154.2
      Conserved Domains (1) summary
      pfam07984
      Location:9 → 326
      NTP_transf_7; Nucleotidyltransferase

    2. NM_001271008.1 → NP_001257937.1  terminal nucleotidyltransferase 5D

      See identical proteins and their annotated locations for NP_001257937.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK133246, AL669851
      Consensus CDS
      CCDS53172.1
      UniProtKB/TrEMBL
      B1ATX6
      Related
      ENSMUSP00000098850.3, ENSMUST00000101292.9
      Conserved Domains (1) summary
      pfam07984
      Location:9 → 326
      NTP_transf_7; Nucleotidyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      106836196..106916517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527936.2 → XP_006527999.1  terminal nucleotidyltransferase 5D isoform X1

      See identical proteins and their annotated locations for XP_006527999.1

      UniProtKB/TrEMBL
      B1ATX6
      Conserved Domains (1) summary
      pfam07984
      Location:9 → 326
      NTP_transf_7; Nucleotidyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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