Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn22provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)provided by MGI
Primary source: MGI:MGI:107170
See related: Ensembl:ENSMUSG00000027843 AllianceGenome:MGI:107170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PEP; Ptpn8; 70zpep
Summary: Enables SH3 domain binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including dephosphorylation; regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within T cell differentiation and T cell receptor signaling pathway. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 5.9), thymus adult (RPKM 4.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.52 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (103763891..103819568)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (103856575..103912252)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
Title: Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease.
Title: PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease.
Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
Title: Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice.
Title: Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice.
Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.
Title: Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
Title: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors.
Title: Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors.
Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization.
Title: Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization.
Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.
Title: Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.
Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis.
Title: Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (9) 1 citation

General gene information

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Markers

M90388 (e-PCR)
- UniSTS:124998

D3Mit266 (e-PCR), detects polymorphism
- UniSTS:129694

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in phosphoanandamide dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granzyme B production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein K63-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 22

Names: PEST domain-enriched tyrosine phosphatase; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; protein tyrosine phosphatase, non-receptor type 8

NP_001396723.1

EC 3.1.3.48

NP_001396724.1

EC 3.1.3.48

NP_033005.1

EC 3.1.3.48

XP_006501211.1

EC 3.1.3.48

XP_006501212.1

EC 3.1.3.48

XP_006501213.1

EC 3.1.3.48

XP_011238343.1

EC 3.1.3.48

XP_011238344.1

EC 3.1.3.48

XP_017174993.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409794.1 → NP_001396723.1 tyrosine-protein phosphatase non-receptor type 22 isoform 1

Status: VALIDATED

Source sequence(s)

AC124698

UniProtKB/Swiss-Prot

P29352, Q7TMP9
NM_001409795.1 → NP_001396724.1 tyrosine-protein phosphatase non-receptor type 22 isoform 2

Status: VALIDATED

Source sequence(s)

AC124698
NM_008979.3 → NP_033005.1 tyrosine-protein phosphatase non-receptor type 22 isoform 1

See identical proteins and their annotated locations for NP_033005.1

Status: VALIDATED

Source sequence(s)

AC124698

Consensus CDS

CCDS38577.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Related

ENSMUSP00000029433.8, ENSMUST00000029433.9

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22

RNA

NR_104070.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124698

Related

ENSMUST00000146071.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

103763891..103819568

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501148.4 → XP_006501211.1 tyrosine-protein phosphatase non-receptor type 22 isoform X1

See identical proteins and their annotated locations for XP_006501211.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
XM_006501149.4 → XP_006501212.1 tyrosine-protein phosphatase non-receptor type 22 isoform X1

See identical proteins and their annotated locations for XP_006501212.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
XM_006501150.3 → XP_006501213.1 tyrosine-protein phosphatase non-receptor type 22 isoform X1

See identical proteins and their annotated locations for XP_006501213.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
XM_011240041.3 → XP_011238343.1 tyrosine-protein phosphatase non-receptor type 22 isoform X1

See identical proteins and their annotated locations for XP_011238343.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
XM_011240042.3 → XP_011238344.1 tyrosine-protein phosphatase non-receptor type 22 isoform X1

See identical proteins and their annotated locations for XP_011238344.1

UniProtKB/Swiss-Prot

P29352, Q7TMP9

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cd14602
Location:57 → 290

PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
XM_017319504.3 → XP_017174993.1 tyrosine-protein phosphatase non-receptor type 22 isoform X2

UniProtKB/TrEMBL

E9QAS3

Conserved Domains (1) summary

cl28904
Location:1 → 175

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily