U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ptafr platelet-activating factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 19204, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ptafrprovided by MGI
    Official Full Name
    platelet-activating factor receptorprovided by MGI
    Primary source
    MGI:MGI:106066
    See related
    Ensembl:ENSMUSG00000056529 AllianceGenome:MGI:106066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAFR
    Summary
    This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in mammary gland adult (RPKM 12.2), subcutaneous fat pad adult (RPKM 7.6) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptafr in Genome Data Viewer
    Location:
    4 D2.3; 4 65.56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132291378..132309994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132564067..132582683)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene predicted gene, 24762 Neighboring gene predicted gene, 54261 Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene EYA transcriptional coactivator and phosphatase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene X-linked Kx blood group related 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables lipopolysaccharide immune receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables mitogen-activated protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet activating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet activating factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gravity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inositol trisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in parturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular extravasation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gastro-intestinal system smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gastro-intestinal system smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of maternal process involved in parturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to symbiotic bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    platelet-activating factor receptor
    Names
    PAF receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081211.3NP_001074680.1  platelet-activating factor receptor

      See identical proteins and their annotated locations for NP_001074680.1

      Status: VALIDATED

      Source sequence(s)
      AL805897, CR931794
      Consensus CDS
      CCDS38899.1
      UniProtKB/Swiss-Prot
      B1B170, Q62035, Q8C017
      Related
      ENSMUSP00000070925.8, ENSMUST00000070690.8
      Conserved Domains (1) summary
      pfam00001
      Location:33292
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132291378..132309994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)