Psmb1 proteasome (prosome, macropain) subunit, beta type 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb1provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type 1provided by MGI
Primary source: MGI:MGI:104884
See related: Ensembl:ENSMUSG00000014769 AllianceGenome:MGI:104884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmpc5
Summary: Predicted to be involved in proteolysis involved in protein catabolic process. Part of proteasome core complex. Is expressed in central nervous system; dorsal root ganglion; integumental system; rib; and sensory organ. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 121.4), large intestine adult (RPKM 112.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A2; 17 8.95 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (15695983..15718538, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (15475721..15498276, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1.
Title: Regulation of proteasome activity by P2Y(2) receptor underlies the neuroprotective effects of extracellular nucleotides.
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10.
Title: Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124815 (e-PCR)
- UniSTS:161637

C81484 (e-PCR)
- UniSTS:209272

RH127091 (e-PCR)
- UniSTS:209788

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit beta type-1

Names: beta-6; component C5 of proteasome; macropain subunit C5; multicatalytic endopeptidase complex subunit C5; proteasome beta-subunit C5; proteasome component C5; proteasome gamma chain; proteasome subunit C5; proteasome subunit beta-6

NP_035315.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011185.3 → NP_035315.1 proteasome subunit beta type-1

See identical proteins and their annotated locations for NP_035315.1

Status: PROVISIONAL

Source sequence(s)

AK132161

Consensus CDS

CCDS28411.1

UniProtKB/Swiss-Prot

O09061, Q62038, Q62039

UniProtKB/TrEMBL

Q6RI64

Related

ENSMUSP00000014913.9, ENSMUST00000014913.11

Conserved Domains (2) summary

COG0638
Location:18 → 240

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03757
Location:29 → 240

proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...