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    Pde9a phosphodiesterase 9A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191569, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Pde9aprovided by RGD
    Official Full Name
    phosphodiesterase 9Aprovided by RGD
    Primary source
    RGD:621035
    See related
    EnsemblRapid:ENSRNOG00000001174 AllianceGenome:RGD:621035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP-mediated signaling. Located in perikaryon. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 75.8), Kidney (RPKM 67.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9471136..9564286)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9469809..9562949)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10123624..10216325)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098980 Neighboring gene solute carrier family 37 member 1 Neighboring gene uncharacterized LOC120098916 Neighboring gene uncharacterized LOC103694394 Neighboring gene uncharacterized LOC134483878 Neighboring gene WD repeat domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. Dungan JR, et al. Am Heart J Plus, 2022 May. PMID 35959094, Free PMC Article
    2. CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure. Richards DA, et al. Circ Heart Fail, 2021 Jan. PMID 33464954, Free PMC Article
    3. PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro. Huan X, et al. Neurochem Int, 2020 Feb. PMID 31821840
    4. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents. Rosenbrock H, et al. J Pharmacol Exp Ther, 2019 Dec. PMID 31578258
    5. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Wu Y, et al. J Med Chem, 2019 Apr 25. PMID 30916555

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cGMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    NP_612552.1
    XP_008771015.1
    XP_008771016.1
    XP_008771017.1
    XP_038954338.1
    XP_038954339.1
    XP_063135018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138543.1 → NP_612552.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

      See identical proteins and their annotated locations for NP_612552.1

      Status: PROVISIONAL

      Source sequence(s)
      AF372654
      UniProtKB/Swiss-Prot
      F1LRG6, Q8QZV1
      UniProtKB/TrEMBL
      A0A8I6ALK2
      Related
      ENSRNOP00000001559.7, ENSRNOT00000001559.9
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9471136..9564286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098411.2 → XP_038954339.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

      Conserved Domains (1) summary
      cl21469
      Location:250 → 273
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    2. XM_008772793.4 → XP_008771015.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      See identical proteins and their annotated locations for XP_008771015.1

      UniProtKB/Swiss-Prot
      F1LRG6, Q8QZV1
      UniProtKB/TrEMBL
      A0A8I6ALK2
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_008772794.4 → XP_008771016.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      See identical proteins and their annotated locations for XP_008771016.1

      UniProtKB/Swiss-Prot
      F1LRG6, Q8QZV1
      UniProtKB/TrEMBL
      A0A8I6ALK2
      Related
      ENSRNOP00000110403.1, ENSRNOT00000131269.1
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_008772795.4 → XP_008771017.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      See identical proteins and their annotated locations for XP_008771017.1

      UniProtKB/Swiss-Prot
      F1LRG6, Q8QZV1
      UniProtKB/TrEMBL
      A0A8I6ALK2
      Related
      ENSRNOP00000100376.1, ENSRNOT00000165087.1
      Conserved Domains (1) summary
      pfam00233
      Location:250 → 478
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_063278948.1 → XP_063135018.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AL01, A6JJZ6
      Related
      ENSRNOP00000095194.1, ENSRNOT00000095394.2

    6. XM_039098410.2 → XP_038954338.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AL01, A6JJZ6
      Conserved Domains (1) summary
      pfam00233
      Location:128 → 356
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZV1.1 GenPept UniProtKB/Swiss-Prot:Q8QZV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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