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    kri-1 FERM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191275, updated on 18-Sep-2024

    Summary

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    Official Symbol
    kri-1
    Official Full Name
    FERM domain-containing protein
    Primary source
    WormBase:WBGene00013955
    Locus tag
    CELE_ZK265.1
    See related
    AllianceGenome:WB:WBGene00013955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell redox homeostasis; negative regulation of angiogenesis; and regulation of establishment of cell polarity. Located in apical plasma membrane; apicolateral plasma membrane; and nucleus. Is expressed in intestine and pharynx. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation and cerebral cavernous malformation 1. Orthologous to human KRIT1 (KRIT1 ankyrin repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See kri-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (8226494..8240637, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein;Secreted protein Neighboring gene Nematode Specific Peptide family Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans. Wei Y, et al. Proc Natl Acad Sci U S A, 2016 May 17. PMID 27140632, Free PMC Article
    2. Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Ito S, et al. Curr Biol, 2010 Feb 23. PMID 20137949, Free PMC Article
    3. Generation and Analysis of CCM Phenotypes in C. elegans. Popiel E, et al. Methods Mol Biol, 2020. PMID 32524554
    4. Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Berman JR, et al. Cell, 2006 Mar 10. PMID 16530050
    5. Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations. Ratnappan R, et al. Worm, 2016 Jan-Mar. PMID 27073739, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study define the apoptotic pathway downstream of KRI-1 by conducting a forward genetic mutagenesis screen to restore ionizing radiation-induced apoptosis in kri-1 mutant worms. Proteomic analysis of KRI-1 binding partners identifies the previously uncharacterized protein K07A9.3, which is the ortholog of human CCM2 and a regulator of the ERK-5 pathway.
      Title: A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.
    2. Kri-1 is required to activate DNA damage-dependent cell death of germ cells independently of cep-1/p53.
      Title: Cell-nonautonomous regulation of C. elegans germ cell death by kri-1.
    3. Data show that the reproductive system communicates with the intestine through lipophilic-hormone signaling and that a gene called kri-1 is likely to act in the intestine to promote DAF-16 nuclear localization in response to this signal.
      Title: Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein
    NP_001021863.1
    • Confirmed by transcript evidence
    NP_001021864.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8226494..8240637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026692.6 → NP_001021863.1  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDH0
      Conserved Domains (6) summary
      smart00295
      Location:448 → 645
      B41; Band 4.1 homologues
      cd00204
      Location:305 → 421
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:306 → 401
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:126 → 210
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
      sd00045
      Location:305 → 332
      ANK; ANK repeat [structural motif]
      cl09511
      Location:548 → 645
      FERM_B-lobe; FERM domain B-lobe

    2. NM_001026693.5 → NP_001021864.1  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF18
      Conserved Domains (6) summary
      smart00295
      Location:448 → 645
      B41; Band 4.1 homologues
      cd00204
      Location:305 → 421
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:306 → 401
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:126 → 210
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
      sd00045
      Location:305 → 332
      ANK; ANK repeat [structural motif]
      cl09511
      Location:548 → 645
      FERM_B-lobe; FERM domain B-lobe
    Nucleotide Protein
    Heading Accession and Version

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