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    GPR183 G protein-coupled receptor 183 [ Homo sapiens (human) ]

    Gene ID: 1880, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR183provided by HGNC
    Official Full Name
    G protein-coupled receptor 183provided by HGNC
    Primary source
    HGNC:HGNC:3128
    See related
    Ensembl:ENSG00000169508 MIM:605741; AllianceGenome:HGNC:3128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EBI2; hEBI2
    Summary
    This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 44.7), bone marrow (RPKM 34.8) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR183 in Genome Data Viewer
    Location:
    13q32.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (99294539..99307399, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98504775..98517640, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99946793..99959653, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene uncharacterized LOC124903198 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99914553-99914775 Neighboring gene G protein-coupled receptor 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99955752-99956300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99956301-99956847 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:99966417-99967616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99994828-99995328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99995329-99995829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7934 Neighboring gene FKSG29 Neighboring gene microRNA 623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exploring the Activation Mechanism of the GPR183 Receptor. Hu L, et al. J Phys Chem B, 2024 Jun 27. PMID 38877985
    2. The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems. Rutkowska A, et al. Curr Drug Targets, 2016. PMID 26898310
    3. Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages. Preuss I, et al. Biochem Biophys Res Commun, 2014 Apr 11. PMID 24480442
    4. EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies. Niss Arfelt K, et al. Blood, 2017 Feb 16. PMID 28003273, Free PMC Article
    5. EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis. Clottu AS, et al. Cell Rep, 2017 Jan 3. PMID 28052250

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication.
      Title: The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication.
    2. Exploring the Activation Mechanism of the GPR183 Receptor.
      Title: Exploring the Activation Mechanism of the GPR183 Receptor.
    3. The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
      Title: The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
    4. Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients.
      Title: Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients.
    5. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
      Title: EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
    6. EBI2-expressing B cells in neuromyelitis optica spectrum disorder with AQP4-IgG: Association with acute attacks and serum cytokines.
      Title: EBI2-expressing B cells in neuromyelitis optica spectrum disorder with AQP4-IgG: Association with acute attacks and serum cytokines.
    7. A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease.
      Title: A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease.
    8. GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
      Title: GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
    9. Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced beta-cell dysfunction.
      Title: Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction.
    10. these data implicate the EBI2-oxysterol axis in inflammatory bowel disease pathogenesis
      Title: The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 183 (GPR183) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxysterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxysterol binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T follicular helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in leukocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mature B cell differentiation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of astrocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 183
    Names
    EBV-induced G-protein coupled receptor 2
    Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
    epstein-Barr virus-induced G-protein coupled receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004951.5 → NP_004942.1  G-protein coupled receptor 183

      See identical proteins and their annotated locations for NP_004942.1

      Status: REVIEWED

      Source sequence(s)
      AK313443, AW574697, BC020752
      Consensus CDS
      CCDS9492.1
      UniProtKB/Swiss-Prot
      B2R8N5, P32249, Q53F99, Q5JUH7
      Related
      ENSP00000365596.4, ENST00000376414.5
      Conserved Domains (1) summary
      cd15159
      Location:32 → 319
      7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      99294539..99307399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      98504775..98517640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32249.3 GenPept UniProtKB/Swiss-Prot:P32249

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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