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    Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 18674, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Slc25a3provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3provided by MGI
    Primary source
    MGI:MGI:1353498
    See related
    Ensembl:ENSMUSG00000061904 AllianceGenome:MGI:1353498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP; Phc; 5730556H19Rik
    Summary
    Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 904.7), duodenum adult (RPKM 787.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a3 in Genome Data Viewer
    Location:
    10 C2; 10 45.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90952436..90959902, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91116574..91124046, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27538 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene predicted gene, 25390 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene IKBKB interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene predicted gene, 24119 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene thymopoietin Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes. Harrigan MT, et al. Mol Cell Biol, 1989 Aug. PMID 2552295, Free PMC Article
    2. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD. Nakanishi T, et al. Exp Cell Res, 2023 Oct 1. PMID 37557977
    3. Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome. Peoples JN, et al. Am J Physiol Cell Physiol, 2021 Sep 1. PMID 34319827, Free PMC Article
    4. miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart. Baseler WA, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23034391, Free PMC Article
    5. Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy. Kwong JQ, et al. Cell Death Differ, 2014 Aug. PMID 24658400, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
      Title: METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
    2. SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
      Title: SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
    3. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
      Title: An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
    4. Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
      Title: Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
    5. SLC25A3 is a mitochondrial copper transporter.
      Title: The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis.
    6. The mitochondrial PiC is not a critical component of the MPT pore.
      Title: Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.
    7. The results indicated that miR-141 can regulate Slc25a3 protein expression in the diabetic heart. Further, diabetes-induced miRNA changes may influence mitochondrial proteomes and functional processes such as mitochondrial ATP production.
      Title: miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial phosphate ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 

    General protein information

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    Preferred Names
    solute carrier family 25 member 3
    Names
    phosphate carrier protein, mitochondrial
    phosphate transport protein
    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428746.1 → NP_001415675.1  solute carrier family 25 member 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140410
      UniProtKB/TrEMBL
      G5E902

    2. NM_001428747.1 → NP_001415676.1  solute carrier family 25 member 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140410

    3. NM_133668.5 → NP_598429.1  solute carrier family 25 member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_598429.1

      Status: VALIDATED

      Source sequence(s)
      AC140410
      Consensus CDS
      CCDS24121.1
      UniProtKB/Swiss-Prot
      Q542V7, Q8VEM8
      UniProtKB/TrEMBL
      Q3THU8, Q3U995, Q3UB63
      Related
      ENSMUSP00000075987.7, ENSMUST00000076694.13
      Conserved Domains (2) summary
      PTZ00169
      Location:66 → 332
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:59 → 147
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. NR_190487.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140410

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      90952436..90959902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513371.5 → XP_006513434.1  solute carrier family 25 member 3 isoform X1

      Related
      ENSMUSP00000127098.2, ENSMUST00000170810.8
      Conserved Domains (1) summary
      pfam00153
      Location:60 → 146
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEM8.1 GenPept UniProtKB/Swiss-Prot:Q8VEM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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