Pdcd1 programmed cell death 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdcd1provided by MGI
Official Full Name: programmed cell death 1provided by MGI
Primary source: MGI:MGI:104879
See related: Ensembl:ENSMUSG00000026285 AllianceGenome:MGI:104879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PD-1; Pdc1; Ly101
Summary: Predicted to enable signaling receptor activity. Involved in negative regulation of immune response. Acts upstream of or within negative regulation of B cell apoptotic process; negative regulation of tolerance induction; and positive regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in thymus adult (RPKM 7.6), ovary adult (RPKM 3.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93966027..93980278, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (94038305..94052553, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXO38 is dispensable for PD-1 regulation.
Title: FBXO38 is dispensable for PD-1 regulation.
Roles of programmed death-1 and muscle innate lymphoid cell-derived interleukin 13 in sepsis-induced intensive care unit-acquired weakness.
Title: Roles of programmed death-1 and muscle innate lymphoid cell-derived interleukin 13 in sepsis-induced intensive care unit-acquired weakness.
Androgen aggravates aortic aneurysms via suppression of PD-1 in mice.
Title: Androgen aggravates aortic aneurysms via suppression of PD-1 in mice.
PD-1 regulates ILC3-driven intestinal immunity and homeostasis.
Title: PD-1 regulates ILC3-driven intestinal immunity and homeostasis.
PD-1 knockout on cytotoxic primary murine CD8[+] T cells improves their motility in retrovirus infected mice.
Title: PD-1 knockout on cytotoxic primary murine CD8(+) T cells improves their motility in retrovirus infected mice.
Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.
Title: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.
PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma.
Title: PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma.
Upregulation of PD-1 and its ligands and expansion of T peripheral helper cells in the nephritic kidneys of lupus-prone BXSB-Yaa mice.
Title: Upregulation of PD-1 and its ligands and expansion of T peripheral helper cells in the nephritic kidneys of lupus-prone BXSB-Yaa mice.
PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Title: PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development.
Title: PD-1 Limits IL-2 Production and Thymic Regulatory T Cell Development.

Submit: New GeneRIF Correction See all GeneRIFs (414)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492862

X67914 (e-PCR)
- UniSTS:163259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell mediated immune response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of regulatory T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: programmed cell death protein 1

Names: mPD-1; programmed cell death 1 protein; protein PD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.