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    Ocm oncomodulin [ Mus musculus (house mouse) ]

    Gene ID: 18261, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ocmprovided by MGI
    Official Full Name
    oncomodulinprovided by MGI
    Primary source
    MGI:MGI:97401
    See related
    Ensembl:ENSMUSG00000029618 AllianceGenome:MGI:97401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium ion binding activity and protein homodimerization activity. Predicted to be involved in response to wounding. Predicted to be located in several cellular components, including cuticular plate; extracellular space; and stereocilium. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in crista ampullaris and utricle. Orthologous to human OCM (oncomodulin) and OCM2 (oncomodulin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 9.7) and small intestine adult (RPKM 3.3) See more
    Orthologs
    human all
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    Genomic context

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    See Ocm in Genome Data Viewer
    Location:
    5 G2; 5 82.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143956615..143987691, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144019807..144050640, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene STARR-positive B cell enhancer ABC_E6396 Neighboring gene predicted gene, 24311 Neighboring gene predicted gene, 54312 Neighboring gene predicted gene, 33427 Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene STARR-seq mESC enhancer starr_14800 Neighboring gene STARR-positive B cell enhancer ABC_E1061 Neighboring gene lemur tyrosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:144923715-144923898

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells. Yang Y, et al. J Physiol, 2023 Oct. PMID 37642186, Free PMC Article
    2. Structure and chromosomal localization of the mouse oncomodulin gene. Staubli F, et al. Mamm Genome, 1995 Nov. PMID 8597631
    3. The intracisternal A particle derived solo LTR promoter of the rat oncomodulin gene is not present in the mouse gene. Banville D, et al. Genetica, 1992. PMID 1468649
    4. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice. Niemi JP, et al. eNeuro, 2022 Jan-Feb. PMID 35131866, Free PMC Article
    5. Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice. Climer LK, et al. Front Aging Neurosci, 2021. PMID 34867279, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.
      Title: Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.
    2. Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.
      Title: Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.
    3. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice.
      Title: The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice.
    4. These data suggest that Ocm may have distinct functional roles in cochlear and vestibular hair cells.
      Title: Oncomodulin identifies different hair cell types in the mammalian inner ear.
    5. absence of parvalbumin has no major effect on the GABA-synthesizing system in diencephalon presynaptic terminals; however, a likely homeostatic mechanism is induced resulting in the upregulation of oncomodulin in selected axons and neuronal perikarya
      Title: Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cuticular plate IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cuticular plate ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in supramolecular fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in supramolecular fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oncomodulin
    Names
    OM
    parvalbumin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033039.3 → NP_149028.2  oncomodulin

      See identical proteins and their annotated locations for NP_149028.2

      Status: VALIDATED

      Source sequence(s)
      AC121917
      Consensus CDS
      CCDS51693.1
      UniProtKB/Swiss-Prot
      P51879, Q62004
      Related
      ENSMUSP00000031622.7, ENSMUST00000031622.13
      Conserved Domains (1) summary
      cd16255
      Location:9 → 109
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143956615..143987691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241003.2 → XP_011239305.1  oncomodulin isoform X1

      See identical proteins and their annotated locations for XP_011239305.1

      Conserved Domains (1) summary
      cd16255
      Location:9 → 103
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    2. XM_011241004.2 → XP_011239306.1  oncomodulin isoform X1

      See identical proteins and their annotated locations for XP_011239306.1

      Conserved Domains (1) summary
      cd16255
      Location:9 → 103
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    3. XM_011241005.4 → XP_011239307.1  oncomodulin isoform X1

      See identical proteins and their annotated locations for XP_011239307.1

      Conserved Domains (1) summary
      cd16255
      Location:9 → 103
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

    4. XM_036164868.1 → XP_036020761.1  oncomodulin isoform X1

      Conserved Domains (1) summary
      cd16255
      Location:9 → 103
      EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51879.2 GenPept UniProtKB/Swiss-Prot:P51879

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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