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    obr-3 PH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181495, updated on 18-Sep-2024

    Summary

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    Official Symbol
    obr-3
    Official Full Name
    PH domain-containing protein
    Primary source
    WormBase:WBGene00014215
    Locus tag
    CELE_ZK1086.1
    See related
    AllianceGenome:WB:WBGene00014215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cholesterol binding activity and sterol transporter activity. Involved in regulation of growth and transforming growth factor beta receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in hypodermis; neurons; and pharyngeal muscle cell. Orthologous to several human genes including OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See obr-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (13798210..13809873, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene Protein lifeguard 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Sugawara K, et al. Genes Cells, 2001 Jul. PMID 11473578
    2. A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity. Stumpf CR, et al. RNA, 2008 Aug. PMID 18579869, Free PMC Article
    3. The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation. Wang M, et al. Int J Mol Sci, 2018 Jan 30. PMID 29385744, Free PMC Article
    4. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PH domain-containing protein
    NP_001379311.1
    • Confirmed by transcript evidence
    NP_741923.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13798210..13809873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171794.7 → NP_741923.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC19
      Conserved Domains (2) summary
      cd13286
      Location:33 → 165
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:271 → 599
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001392877.1 → NP_001379311.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPR9
      Conserved Domains (2) summary
      cd13286
      Location:70 → 202
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:308 → 631
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version

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